ArticleBiophysical journal2006
Torsional rigidities of weakly strained DNAs.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A Primer on the oxDNA Model of DNA: When to Use it, How to Simulate it and How to Interpret the Results.Frontiers in molecular biosciences · 2021Review
- Explaining the striking difference in twist-stretch coupling between DNA and RNA: A comparative molecular dynamics analysis.Nucleic acids research · 2015Article
- DNA supercoiling: a regulatory signal for the λ repressor.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Efficient deformation algorithm for plasmid DNA simulations.BMC bioinformatics · 2014Article
- Blind predictions of DNA and RNA tweezers experiments with force and torque.PLoS computational biology · 2014Article
- Structural ensemble and microscopic elasticity of freely diffusing DNA by direct measurement of fluctuations.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- DNA on a tube: electrostatic contribution to stiffness.The journal of physical chemistry. B · 2008Article
- A structural transition in duplex DNA induced by ethylene glycol.The journal of physical chemistry. B · 2008Article
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3 authors.
Funding
Abstract
Measurements on unstrained linear and weakly strained large (> or =340 bp) circular DNAs yield torsional rigidities in the range C = 170-230 fJ fm. However, larger values, in the range C = 270-420 fJ fm, are typically obtained from measurements on sufficiently small (< or =247 bp) circular DNAs, and values in the range C = 300-450 fJ fm are obtained from experiments on linear DNAs under tension. A new method is proposed to estimate torsional rigidities of weakly supercoiled circular DNAs. Monte Carlo simulations of the supercoiling free energies of solution DNAs, and also of the structures of surface-confined supercoiled plasmids, were performed using different trial values of C. The results are compared with experimental measurements of the twist energy parameter, E(T), that governs the supercoiling free energy, and also with atomic force microscopy images of surface-confined plasmids. The results clearly demonstrate that C-values in the range 170-230 fJ fm are compatible with experimental observations, whereas values in the range C > or = 269 fJ fm, are incompatible with those same measurements. These results strongly suggest that the secondary structure of DNA is altered by either sufficient coherent bending strain or sufficient tension so as to enhance its torsional rigidity.
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