ArticleBiophysical journal2006
Quantitative analysis of the role of receptor recycling in T cell polarization.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Systems biomechanics of centrosome positioning: A conserved complexity.Communicative & integrative biology · 2011Article
- Symmetry, stability, and reversibility properties of idealized confined microtubule cytoskeletons.Biophysical journal · 2010Article
- Integrating receptor signal inputs that influence small Rho GTPase activation dynamics at the immunological synapse.Molecular and cellular biology · 2009Article
- Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.The Journal of biological chemistry · 2008Article
- Retractile processes in T lymphocyte orientation on a stimulatory substrate: morphology and dynamics.Physical biology · 2008Article
- An experimental and computational study of effects of microtubule stabilization on T-cell polarity.PloS one · 2008Article
- A model for the interplay of receptor recycling and receptor-mediated contact in T cells.PloS one · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Activation of T cells of the immune system involves recognition of the antigen by the T cell receptor and subsequent internalization and recycling of this receptor. We present a numerical model for this process that accounts for the polarity of the intracellular traffic determined by the polarization of the microtubule-organizing center to the immunological synapse. Unexpectedly, the model explains the observed accumulation of receptors at the immunological synapse mainly as dynamic maintenance of the receptor density there, while the surface receptors everywhere else are depleted, even though the internalization occurs primarily at the synapse. In the case of an unsuccessful polarization of the microtubule-organizing center, which alters the polarity of the receptor trafficking, the model explains the absence of receptor accumulation as a dynamic downregulation at the synapse. The experiment shows that in this case the interaction of the T cell with its target is aborted. Disruption of recycling leads in the experiment to accumulation of the incompletely polarized cells. We propose that receptor recycling is a mechanism whereby the cell can sense its internal structure and detect polarity errors, analogous to checkpoint signaling mechanisms that ensure fidelity of cell division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.