ArticleNucleic acids research2006
Codon usage bias and tRNA over-expression in Buchnera aphidicola after aromatic amino acid nutritional stress on its host Acyrthosiphon pisum.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Risk Assessment of the Possible Intermediate Host Role of Pigs for Coronaviruses with a Deep Learning Predictor.Viruses · 2023Article
- Deep learning based on biologically interpretable genome representation predicts two types of human adaptation of SARS-CoV-2 variants.Briefings in bioinformatics · 2022Article
- Isolation of the Buchnera aphidicola flagellum basal body complexes from the Buchnera membrane.PloS one · 2021Article
- Comparative Genomics of Two Closely Related Wolbachia with Different Reproductive Effects on Hosts.Genome biology and evolution · 2016Article
- The Rare Codon AGA Is Involved in Regulation of Pyoluteorin Biosynthesis in Pseudomonas protegens Pf-5.Frontiers in microbiology · 2016Article
- Analysis of synonymous codon usage patterns in torque teno sus virus 1 (TTSuV1).Archives of virology · 2013Article
- Altered tRNA characteristics and 3' maturation in bacterial symbionts with reduced genomes.Nucleic acids research · 2012Article
- Multimodal dynamic response of the Buchnera aphidicola pLeu plasmid to variations in leucine demand of its host, the pea aphid Acyrthosiphon pisum.Molecular microbiology · 2011Article
- Translational selection is ubiquitous in prokaryotes.PLoS genetics · 2010Article
- Comparative analysis of nuclear tRNA genes of Nasonia vitripennis and other arthropods, and relationships to codon usage bias.Insect molecular biology · 2010Article
- Conservation of the links between gene transcription and chromosomal organization in the highly reduced genome of Buchnera aphidicola.BMC genomics · 2007Article
- Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiation.Nucleic acids research · 2007Article
- Different levels of transcriptional regulation due to trophic constraints in the reduced genome of Buchnera aphidicola APS.Applied and environmental microbiology · 2006Article
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Abstract
Codon usage bias and relative abundances of tRNA isoacceptors were analysed in the obligate intracellular symbiotic bacterium, Buchnera aphidicola from the aphid Acyrthosiphon pisum, using a dedicated 35mer oligonucleotide microarray. Buchnera is archetypal of organisms living with minimal metabolic requirements and presents a reduced genome with high-evolutionary rate. Codonusage in Buchnera has been overcome by the high mutational bias towards AT bases. However, several lines of evidence for codon usage selection are given here. A significant correlation was found between tRNA relative abundances and codon composition of Buchnera genes. A significant codon usage bias was found for the choice of rare codons in Buchnera: C-ending codons are preferred in highly expressed genes, whereas G-ending codons are avoided. This bias is not explained by GC skew in the bacteria and might correspond to a selection for perfect matching between codon-anticodon pairs for some essential amino acids in Buchnera proteins. Nutritional stress applied to the aphid host induced a significant overexpression of most of the tRNA isoacceptors in bacteria. Although, molecular regulation of the tRNA operons in Buchnera was not investigated, a correlation between relative expression levels and organization in transcription unit was found in the genome of Buchnera.
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