ArticleJournal of the American Society for Mass Spectrometry2006
Charge location directs electron capture dissociation of peptide dications.
Article in Journal of the American Society for Mass Spectrometry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- On the mechanism of protein supercharging in electrospray ionisation mass spectrometry: Effects on charging of additives with short- and long-chain alkyl constituents with carbonate and sulphite terminal groups.Analytica chimica acta: X · 2019Article
- Where Does the Electron Go? Stable and Metastable Peptide Cation Radicals Formed by Electron Transfer.Journal of the American Society for Mass Spectrometry · 2017Article
- Protein Structural Analysis via Mass Spectrometry-Based Proteomics.Advances in experimental medicine and biology · 2016Review
- Electron Capture Dissociation of Sodium-Adducted Peptides on a Modified Quadrupole/Time-of-Flight Mass Spectrometer.Journal of the American Society for Mass Spectrometry · 2015Article
- Cation recombination energy/coulomb repulsion effects in ETD/ECD as revealed by variation of charge per residue at fixed total charge.Journal of the American Society for Mass Spectrometry · 2013Article
- Electron capture dissociation of hydrogen-deficient peptide radical cations.Journal of the American Society for Mass Spectrometry · 2012Article
- ECD-like peptide fragmentation at atmospheric pressure.International journal of mass spectrometry · 2012Article
- Charge-site-dependent dissociation of hydrogen-rich radical peptide cations upon vacuum UV photoexcitation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2012Article
- Electron induced dissociation of singly deprotonated peptides.Journal of the American Society for Mass Spectrometry · 2011Article
- Unusual fragmentation of β-linked peptides by ExD tandem mass spectrometry.Journal of the American Society for Mass Spectrometry · 2011Article
- Electron-capture and -transfer dissociation of peptides tagged with tunable fixed-charge groups: structures and dissociation energetics.Journal of the American Society for Mass Spectrometry · 2011Article
- Periodic sequence distribution of product ion abundances in electron capture dissociation of amphipathic peptides and proteins.Journal of the American Society for Mass Spectrometry · 2009Article
- Electron capture and transfer dissociation: Peptide structure analysis at different ion internal energy levels.Journal of the American Society for Mass Spectrometry · 2009Article
- Electron-capture-induced dissociation of protoporphyrin IX ions.Journal of the American Society for Mass Spectrometry · 2008Article
- Abundant b-type ions produced in electron capture dissociation of peptides without basic amino acid residues.Journal of the American Society for Mass Spectrometry · 2007Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of peptide dication charge location on electron capture dissociation (ECD) fragmentation pattern is investigated. ECD fragmentation patterns are compared for peptides with amide and free acid C-terminal groups. ECD of free acid compared with C-terminally amidated peptides with basic residues near the N-terminus demonstrates increased formation of a-type ions. Similarly, ECD of free acid compared with C-terminally amidated peptides with basic residues near the C-terminus exhibits increased formation of y-type ions. Alteration of the peptide sequence to inhibit the formation of charged side chains (i.e., amino acid substitution and acetylation) provides further evidence for charge location effect on ECD. We propose that formation of zwitterionic peptide structures increases the likelihood of amide nitrogen protonation (versus basic side chains), which is responsible for the increase in a- and y-type ion formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.