ArticleThe Journal of nutritional biochemistry2007
Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared with those who do not.
Article in The Journal of nutritional biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 71 citations in OpenAlex.
- Soy food supplementation, dietary fat reduction and peripheral blood gene expression in postmenopausal women--a randomized, controlled trial.Molecular nutrition & food research · 2011Trial
- The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women.The American journal of clinical nutrition · 2010Trial
- Phase II trial of isoflavone in prostate-specific antigen recurrent prostate cancer after previous local therapy.BMC cancer · 2008Trial
- Isoflavone-enriched soybean leaves (Glycine max) restore loss of dermal collagen fibers induced by ovariectomy in the Sprague Dawley rats.Laboratory animal research · 2024Article
- Next generation risk assessment of human exposure to estrogens using safe comparator compound values based on in vitro bioactivity assays.Archives of toxicology · 2023Article
- Eat4Genes: a bioinformatic rational gene targeting app and prototype model for improving human health.Frontiers in nutrition · 2023Article
- Omics Technology for the Promotion of Nutraceuticals and Functional Foods.Frontiers in physiology · 2022Review
- Targeted Approaches for In Situ Gut Microbiome Manipulation.JPEN. Journal of parenteral and enteral nutrition · 2020Article
- In vitro-in silico-based analysis of the dose-dependent in vivo oestrogenicity of the soy phytoestrogen genistein in humans.British journal of pharmacology · 2017Article
- Metabolic programming of a beige adipocyte phenotype by genistein.Molecular nutrition & food research · 2017Article
- Isoflavones, their Glycosides and Glycoconjugates. Synthesis and Biological Activity.Current organic chemistry · 2017Review
- Plasma equol concentration is not associated with breast cancer and fibrocystic breast conditions among women in Shanghai, China.Nutrition research (New York, N.Y.) · 2016Article
- S-(-)equol production is developmentally regulated and related to early diet composition.Nutrition research (New York, N.Y.) · 2014Article
- Dietary factors influence production of the soy isoflavone metabolite s-(-)equol in healthy adults.The Journal of nutrition · 2013Article
- Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research.Current nutrition reports · 2013Article
- Inter-individual differences in response to dietary intervention: integrating omics platforms towards personalised dietary recommendations.The Proceedings of the Nutrition Society · 2013Article
- Endogenous and exogenous equol are antiestrogenic in reproductive tissues of apolipoprotein e-null mice.The Journal of nutrition · 2012Article
- Does equol production determine soy endocrine effects?European journal of nutrition · 2012Review
- The microbiota is essential for the generation of black tea theaflavins-derived metabolites.PloS one · 2012Article
- Estrogen receptor β-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause.Menopause (New York, N.Y.) · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Human and animal studies suggest that dietary soy isoflavones reduce cancer risk, ameliorate postmenopausal syndrome and decrease bone resorption in postmenopausal women. The capacity to form the metabolite equol from daidzein is suggested as an important modulator of response to isoflavones; this capacity depends on gut colonization with appropriate bacteria. We administered a dietary supplement containing high-dose purified soy isoflavones (genistein, 558 mg/day; daidzein, 296 mg/day; and glycitein, 44 mg/day) to 30 postmenopausal women for 84 days and collected peripheral lymphocytes at timed intervals. Using microarray analysis, we determined whether changes in gene expression associated with this treatment support existing hypotheses as to isoflavones' mechanisms of action. Expression of a large number of genes was altered by isoflavone treatment, including induction of genes associated with cyclic adenosine 3',5'-monophosphate (cAMP) signaling and cell differentiation and decreased expression of genes associated with cyclin-dependent kinase activity and cell division. We report that isoflavone treatment in subjects who have the capacity to produce equol differentially affects gene expression as compared with nonproducers, supporting the plausibility of the importance of equol production. In general, isoflavones had a stronger effect on some putative estrogen-responsive genes in equol producers than in nonproducers. Our study suggests that, in humans, isoflavone changes are related to increased cell differentiation, increased cAMP signaling and G-protein-coupled protein metabolism and increased steroid hormone receptor activity and have some estrogen agonist effects; equol-production status is likely to be an important modulator of responses to isoflavones.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.