ArticleClinical and vaccine immunology : CVI2006
Essential roles of monocytes in stimulating human peripheral blood mononuclear cells with Lactobacillus casei to produce cytokines and augment natural killer cell activity.
Article in Clinical and vaccine immunology : CVI, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 94 citations in OpenAlex.
- Daily Intake of Fermented Milk ContainingNutrients · 2019Trial
- Daily intake of fermented milk with Lactobacillus casei strain Shirota reduces the incidence and duration of upper respiratory tract infections in healthy middle-aged office workers.European journal of nutrition · 2017Trial
- Effects of the enteral administration of Bifidobacterium breve on patients undergoing chemotherapy for pediatric malignancies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2010Trial
- Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota.Clinical and experimental immunology · 2006Trial
- The interplay of dietary sugar, chronic inflammation, and bladder cancer: mechanistic insights, evidence, and prevention strategies.Frontiers in immunology · 2026Review
- Article
- Diverse impact of a probiotic strain,Bioscience of microbiota, food and health · 2023Article
- Live or Heat-KilledInternational journal of molecular sciences · 2022Article
- Bacteria for Treatment: Microbiome in Bladder Cancer.Biomedicines · 2022Review
- Article
- Dietary Supplementation with FermentedNutrients · 2021Article
- Probiotics into outer space: feasibility assessments of encapsulated freeze-dried probiotics during 1 month's storage on the International Space Station.Scientific reports · 2018Article
- Stimulation of murine cell-mediated immunity by dietary administration of a cell preparation ofBioscience of microbiota, food and health · 2018Article
- Review
- Article
- Activation of Natural Killer Cells by Probiotics.Forum on immunopathological diseases and therapeutics · 2016Article
- Live and Heat-Killed Lactobacillus rhamnosus ATCC 7469 May Induce Modulatory Cytokines Profiles on Macrophages RAW 264.7.TheScientificWorldJournal · 2015Article
- Probiotics as efficient immunopotentiators: translational role in cancer prevention.The Indian journal of medical research · 2013Review
- Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology.Nutrients · 2013Review
- Effects of the probiotic Lactobacillus animalis in murine Mycobacterium avium subspecies paratuberculosis infection.BMC microbiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the effect of a probiotic strain, Lactobacillus casei strain Shirota, on cytokine production and natural killer (NK) cell activity in human peripheral blood mononuclear cells (PBMNC). The cellular mechanisms of immunoregulation by L. casei strain Shirota were also investigated. L. casei strain Shirota stimulated PBMNC to secrete interleukin-12 (IL-12), gamma interferon (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), and IL-10. However, depletion of monocytes from PBMNC eliminated the induction of these cytokines. L. casei strain Shirota was phagocytosed by monocytes and directly stimulated them to secrete IL-12, TNF-alpha, and IL-10. IFN-gamma production was diminished by the addition of anti-IL-12 antibody to the PBMNC cultures. Purified T cells, but not NK cells, produced IFN-gamma effectively when stimulated with L. casei strain Shirota in the presence of monocytes, indicating that monocytes triggered by L. casei strain Shirota help T cells to produce IFN-gamma through secreting IL-12. In addition, NK cell activity and CD69 expression on NK cells increased after cultivation of PBMNC with L. casei strain Shirota. When monocytes were depleted from PBMNC, L. casei strain Shirota did not enhance NK cell activity. These results demonstrate that monocytes play critical roles in the induction of cytokines and following the augmentation of NK cell activity during the stimulation of human PBMNC with L. casei strain Shirota.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.