ArticleThe Journal of physiology2006
Regional variations in the glial influence on synapse development in the mouse CNS.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
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- Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders.Nature neuroscience · 2022Article
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- A Functional Signature in the Developing Cerebellum: Evidence From a Preclinical Model of Autism.Frontiers in cell and developmental biology · 2021Article
- New insights on the modeling of the molecular mechanisms underlying neural maps alignment in the midbrain.eLife · 2020Article
- Age-related changes in regiospecific expression of Lipolysis Stimulated Receptor (LSR) in mice brain.PloS one · 2019Article
- Heterogeneity in Synaptogenic Profile of Astrocytes from Different Brain Regions.Molecular neurobiology · 2018Article
- Article
- Reversal of Pathologic Lipid Accumulation in NPC1-Deficient Neurons by Drug-Promoted Release of LAMP1-Coated Lamellar Inclusions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Astrocytes increase the activity of synaptic GluN2B NMDA receptors.Frontiers in cellular neuroscience · 2015Article
- Autonomous CaMKII requires further stimulation by Ca2+/calmodulin for enhancing synaptic strength.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Pigment epithelium-derived factor released by Müller glial cells exerts neuroprotective effects on retinal ganglion cells.Neurochemical research · 2012Article
- Critical time window of neuronal cholesterol synthesis during neurite outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.Nature · 2012Article
- Ca(2+) channel currents of cortical neurons from pure and mixed cultures.Cytotechnology · 2012Article
- Multifunctionalized electrospun silk fibers promote axon regeneration in central nervous system.Advanced functional materials · 2011Article
- Precursor cell biology and the development of astrocyte transplantation therapies: lessons from spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2011Review
- An in vitro assay system for studying synapse formation between nociceptive dorsal root ganglion and dorsal horn neurons.Journal of neuroscience methods · 2010Article
- Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis.Molecular and cellular neurosciences · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing evidence that synapse function depends on interactions with glial cells, namely astrocytes. Studies on specific neurons of the central nervous system (CNS) indicated that glial signals also control synapse development, but it remained unclear whether this is a general principle that applies to other neuronal cell types. To address this question, we developed new methods to immunoisolate neurons from different brain regions of postnatal mice and to culture them in a chemically defined medium. Electrophysiological recordings and immunocytochemical staining revealed vigorous synaptogenesis in hippocampal and cerebellar neurons, but not in retinal ganglion cells (RGCs) in the absence of glial cells. Co-culture with glia promoted synapse formation in RGCs as indicated by a strong increase in the incidence and frequency of action potential-independent miniature synaptic currents, but showed no such effects in hippocampal or cerebellar neurons. On the other hand, glial signals promoted the efficacy of excitatory synapses in all regions as indicated by an increase in the size of spontaneous synaptic events in cerebellar cultures and of miniature synaptic currents in hippocampal neurons and RGCs. Inhibitory synaptic currents remained largely unaffected by glia. Our results indicate that in the mammalian CNS, the way that glial signals promote the development of excitatory synapses depends on the type of neuron.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.