Trial reportJournal of the American Society of Nephrology : JASN2006
Baseline predictors of renal disease progression in the African American Study of Hypertension and Kidney Disease.
Trial report in Journal of the American Society of Nephrology : JASN, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Evidence-based practice guideline for the treatment of CKD.Clinical and experimental nephrology · 2009Guideline
- Longitudinal progression trajectory of GFR among patients with CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2012Trial
- Intensive blood-pressure control in hypertensive chronic kidney disease.The New England journal of medicine · 2010Trial
- CYP3A4 and CYP3A5 polymorphisms and blood pressure response to amlodipine among African-American men and women with early hypertensive renal disease.American journal of nephrology · 2010Trial
- Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function.Clinical journal of the American Society of Nephrology : CJASN · 2009Trial
- Dietary phosphate exposure-strategies to protect vulnerable population groups.Archives of toxicology · 2026Review
- The effects of elevated phosphate on the kidney - damaging the gatekeeper.Pflugers Archiv : European journal of physiology · 2026Review
- The true cost of phosphate control in chronic kidney disease.Clinical kidney journal · 2025Article
- Association of hyperphosphatemia with renal prognosis in patients with autosomal dominant polycystic kidney disease.Clinical and experimental nephrology · 2025Article
- WHEN PHYSIOLOGY MEETS THE BUILT ENVIRONMENT: THE PHOSPHORUS STORY.Transactions of the American Clinical and Climatological Association · 2025Review
- High Protein Diets and Glomerular Hyperfiltration in Athletes and Bodybuilders: Is Chronic Kidney Disease the Real Finish Line?Sports medicine (Auckland, N.Z.) · 2024Review
- The association of normal-range serum phosphorus with immunoglobulin A nephropathy progression: a retrospective cohort study.International urology and nephrology · 2024Article
- The Usefulness of Calcium/Magnesium Ratio in the Risk Stratification of Early Onset of Renal Replacement Therapy.Diagnostics (Basel, Switzerland) · 2022Article
- Serum phosphate and chronic kidney and cardiovascular disease: Phosphorus potential implications in general population.World journal of nephrology · 2021Review
- Renal function decline in older men and women with advanced chronic kidney disease-results from the EQUAL study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Article
- Increased Lifetime Risk of ESRD in Familial IgA Nephropathy.Kidney international reports · 2021Article
- Abnormal circadian rhythm of urinary sodium excretion correlates closely with hypertension and target organ damage in Chinese patients with CKD.International journal of medical sciences · 2020Article
- Association of Dietary Potassium Intake with the Development of Chronic Kidney Disease and Renal Function in Patients with Mildly Decreased Kidney Function: The Korean Multi-Rural Communities Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Sex-Related Disparities in CKD Progression.Journal of the American Society of Nephrology : JASN · 2019Observational
- microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stress.PloS one · 2019Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
Patients with chronic kidney disease have an increased risk for progression to ESRD. The purpose of this study was to examine factors that predict increased risk for adverse renal outcomes. Cox regression was performed to assess the potential of 38 baseline risk factors to predict the clinical renal composite outcome of 50% or 25-ml/min per 1.73 m(2) GFR decline or ESRD among 1094 black patients with hypertensive nephrosclerosis (GFR 20 to 65 ml/min per 1.73 m(2)). Patients were trial participants who had been randomly assigned to one of two BP goals and to one of three antihypertensive regimens and followed for a range of 3 to 6.4 yr. In unadjusted and adjusted analyses, baseline proteinuria was consistently associated with an increased risk for adverse renal outcomes, even at low levels of proteinuria. The relationship of proteinuria with adverse renal outcomes also was evident in analyses that were stratified by level of GFR, which itself was associated with adverse renal outcomes but only at levels <40 ml/min. Other factors that were significantly associated with increased renal events after adjustment for baseline GFR, age, and gender, both with and without adjustment for baseline proteinuria, included serum creatinine, urea nitrogen, and phosphorus. In black patients with hypertensive nephrosclerosis, increased proteinuria, reduced GFR, and elevated levels of serum creatinine, urea nitrogen and phosphorus were directly associated with adverse clinical renal events. These findings identify a subset of this high-risk population that might benefit from even more aggressive treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.