ArticleNeurochemistry international2007
Mapping convulsants' binding to the GABA-A receptor chloride ionophore: a proposed model for channel binding sites.
Article in Neurochemistry international, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
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- Antibody induced seizure susceptibility and impaired cognitive performance in a passive transfer rat model of autoimmune encephalitis.Frontiers in immunology · 2023Article
- Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis.Communications biology · 2021Article
- GABAJournal, genetic engineering & biotechnology · 2021Review
- Physiological and Biochemical Markers of the Sex-Specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model.Pharmaceuticals (Basel, Switzerland) · 2021Article
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- Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons - Implications for energy balance and glucose control.Molecular metabolism · 2019Article
- NMDA-receptor antibodies alter cortical microcircuit dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Calcium imaging and dynamic causal modelling reveal brain-wide changes in effective connectivity and synaptic dynamics during epileptic seizures.PLoS computational biology · 2018Article
- Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptors.British journal of pharmacology · 2018Article
- Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization.The Journal of physiology · 2012Article
- RDX binds to the GABA(A) receptor-convulsant site and blocks GABA(A) receptor-mediated currents in the amygdala: a mechanism for RDX-induced seizures.Environmental health perspectives · 2011Article
- The channel-lining 6' amino acid in the second membrane-spanning region of ionotropic GABA receptors has more profound effects on 4'-ethynyl-4-n-propylbicycloorthobenzoate binding than the 2' amino acid.Invertebrate neuroscience : IN · 2007Article
- Anesthetics disrupt growth cone guidance cue sensing through actions on the GABANeurotoxicology and teratologyArticle
Corrections and comments
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1 author at 1 institution in 1 country.
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Abstract
Gamma-aminobutyric acid (GABA) type A receptors play a key role in brain inhibitory neurotransmission, and are ligand-activated chloride channels blocked by numerous convulsant ligands. Here we summarize data on binding of picrotoxin, tetrazoles, beta-lactams, bicyclophosphates, butyrolactones and neurotoxic pesticides to GABA-A ionophore, and discuss functional and structural overlapping of their binding sites. The paper reviews data on convulsants' binding sensitivity to different point mutations in ionophore-lining second trans-membrane domains of GABA-A subunits, and maps possible location of convulsants' sites within the chloride ionophore. We also discuss data on inhibition of glycine, glutamate, serotonin (5-HT3) and N-acetylcholine receptors by GABA-A channel blockers, and examine the applicability of this model to other homologous ionotropic receptors. Positioning various convulsant-binding sites within ionophore of GABA-A receptors, this model enables a better understanding of complex architectonics of ionotropic receptors, and may be used for developing new channel-modulating drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.