ArticlePeptides2006
CRH inhibits NF-kappa B signaling in human melanocytes.
Article in Peptides, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Neuro-immuno-endocrinology of the skin: how environment regulates body homeostasis.Nature reviews. Endocrinology · 2025Review
- Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides.American journal of physiology. Cell physiology · 2022Review
- The Brain-Skin Axis in Psoriasis-Psychological, Psychiatric, Hormonal, and Dermatological Aspects.International journal of molecular sciences · 2022Review
- Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.Nature communications · 2021Article
- Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders.Genes and immunity · 2020Review
- Pathogenesis of psoriasis in the "omic" era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances.Postepy dermatologii i alergologii · 2020Review
- Neural and Endocrinal Pathobiochemistry of Vitiligo: Comparative Study for a Hypothesized Mechanism.Frontiers in endocrinology · 2018Article
- Association between Stress and the HPA Axis in the Atopic Dermatitis.International journal of molecular sciences · 2017Review
- Inflammation in Epileptic Encephalopathies.Advances in protein chemistry and structural biology · 2017Review
- Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes.Molecular and cellular endocrinology · 2016Article
- Stress-related skin disorders.Reviews in endocrine & metabolic disorders · 2016Review
- On the role of skin in the regulation of local and systemic steroidogenic activities.Steroids · 2015Review
- Brain-skin connection: stress, inflammation and skin aging.Inflammation & allergy drug targets · 2014Review
- Key role of CRF in the skin stress response system.Endocrine reviews · 2013Review
- Steroidogenesis in the skin: implications for local immune functions.The Journal of steroid biochemistry and molecular biology · 2013Review
- Endothelin-1 enhances the melanogenesis via MITF-GPNMB pathway.BMB reports · 2013Article
- Putative role of HIF transcriptional activity in melanocytes and melanoma biology.Dermato-endocrinology · 2013Review
- ROS and SOCE: recent advances and controversies in the regulation of STIM and Orai.The Journal of physiology · 2012Review
- Insights into mechanisms of corticotropin-releasing hormone receptor signal transduction.British journal of pharmacology · 2012Review
- Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system.Advances in anatomy, embryology, and cell biology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Corticotropin releasing hormone (CRH), a messenger of stress at the central level, is expressed in the epidermis where it operates within local equivalent of hypothalamo-pituitary axis. CRH inhibits NF-kappaB activity in human immortalized epidermal (PIG1) melanocytes. In melanocytes CRH stimulates pro-opiomelanocortin (POMC) mRNA and adrenocorticotropin (ACTH) peptide production. Knockdown of POMC levels by transfecting cells with antisense oligonucleotides blocks the effect of CRH on NF-kappaB signaling indicating that the above inhibition is indirect, e.g. through activation of POMC. We suggest that induction of POMC by CRH serves as a feedback mechanism to self-restrict inflammatory response in the skin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.