ArticleJournal of neuroimmunology2006
The role of the proteasome-ubiquitin pathway in regulation of the IFN-gamma mediated anti-VSV response in neurons.
Article in Journal of neuroimmunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Central angiotensin II-Protein inhibitor of neuronal nitric oxide synthase (PIN) axis contribute to neurogenic hypertension.Nitric oxide : biology and chemistry · 2020Article
- Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay.Scientific reports · 2016Article
- Extended JAK activation and delayed STAT1 dephosphorylation contribute to the distinct signaling profile of CNS neurons exposed to interferon-gamma.Journal of neuroimmunology · 2012Article
- DISTINCT MECHANISMS OF INHIBITION OF VSV REPLICATION IN NEURONS MEDIATED BY TYPE I AND TYPE II IFN.Virus reviews & research : journal of the Brazilian Society for Virology · 2009Article
- Disruption of IFN-gamma- mediated antiviral activity in neurons: the role of cannabinoids.Viral immunology · 2008Article
- PIN: a novel protein involved in IFN-gamma accumulation of NOS-1 in neurons.DNA and cell biology · 2008Article
- Altered levels of STAT1 and STAT3 influence the neuronal response to interferon gamma.Journal of neuroimmunology · 2007Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pharmacologic inhibition of the proteasome resulted in increased NOS-1 protein levels and increased NO production by neuronal cells. This correlated with an increased antiviral effect of IFN-gamma against the replication of vesicular stomatitis virus (VSV) replication in vitro. We also observed that a regulatory protein, Protein Inhibitor of NOS-1 (PIN) was down-regulated by IFN-gamma treatment, and more ubiquitinated PIN accumulated in IFN-gamma treated neurons. In cells of the reticuloendothelial system, IFN-gamma treatment induces the expression of a set of low molecular weight MHC-encoded proteins (LMPs), which replace the beta-subunit of the proteasome complex during the proteasome neosynthesis, resulting in a complex termed the immunoproteasome. LMP2, -7, and -10 were induced and the immunoproteasome was generated by IFN-gamma treatment in neuronal cells. Importantly, we observed that IFN-gamma induced inhibition of VSV protein synthesis was not dependent on ubiquitination.
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