ArticleDevelopmental biology2007
Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Hox genes in development and beyond.Development (Cambridge, England) · 2023Article
- The Neuromeric/Prosomeric Model in Teleost Fish Neurobiology.Brain, behavior and evolution · 2022Review
- Pbx4 limits heart size and fosters arch artery formation by partitioning second heart field progenitors and restricting proliferation.Development (Cambridge, England) · 2020Article
- TALE factors use two distinct functional modes to control an essential zebrafish gene expression program.eLife · 2018Article
- Article
- Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension.Scientific reports · 2017Article
- The origin and evolution of chordate nervous systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- A trans-Regulatory Code for the Forebrain Expression of Six3.2 in the Medaka Fish.The Journal of biological chemistry · 2015Article
- Control of brain patterning by Engrailed paracrine transfer: a new function of the Pbx interaction domain.Development (Cambridge, England) · 2015Article
- An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development.Developmental biology · 2014Article
- TALE factors poise promoters for activation by Hox proteins.Developmental cell · 2014Article
- Novel mechanisms that pattern and shape the midbrain-hindbrain boundary.Cellular and molecular life sciences : CMLS · 2013Review
- Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation.Development (Cambridge, England) · 2012Article
- The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons.Neural development · 2012Article
- Formation of the spinal network in zebrafish determined by domain-specific pax genes.The Journal of comparative neurology · 2011Article
- Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system.Neural development · 2010Article
- Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expression.Development (Cambridge, England) · 2009Article
- Pbx homeodomain proteins pattern both the zebrafish retina and tectum.BMC developmental biology · 2007Article
- FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish.Developmental biology · 2007Article
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5 authors.
Funding
Abstract
Pbx proteins are a family of TALE-class transcription factors that are well characterized as Hox co-factors acting to impart segmental identity to the hindbrain rhombomeres. However, no role for Pbx in establishing more anterior neural compartments has been demonstrated. Studies done in Drosophila show that Engrailed requires Exd (Pbx orthologue) for its biological activity. Here, we present evidence that zebrafish Pbx proteins cooperate with Engrailed to compartmentalize the midbrain by regulating the maintenance of the midbrain-hindbrain boundary (MHB) and the diencephalic-mesencephalic boundary (DMB). Embryos lacking Pbx function correctly initiate midbrain patterning, but fail to maintain eng2a, pax2a, fgf8, gbx2, and wnt1 expression at the MHB. Formation of the DMB is also defective as shown by a caudal expansion of diencephalic epha4a and pax6a expression into midbrain territory. These phenotypes are similar to the phenotype of an Engrailed loss-of-function embryo, supporting the hypothesis that Pbx and Engrailed act together on a common genetic pathway. Consistent with this model, we demonstrate that zebrafish Engrailed and Pbx interact in vitro and that this interaction is required for both the eng2a overexpression phenotype and Engrailed's role in patterning the MHB. Our data support a novel model of midbrain development in which Pbx and Engrailed proteins cooperatively pattern the mesencephalic region of the neural tube.
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