ArticleBMC evolutionary biology2006
Phase distribution of spliceosomal introns: implications for intron origin.
Article in BMC evolutionary biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed.
- Pervasive Conservation of Intron Number and Other Genetic Elements Revealed by a Chromosome-level Genome Assembly of the Hyper-polymorphic Nematode Caenorhabditis brenneri.Genome biology and evolution · 2025Article
- A Broad Genome Survey Reveals Widespread Presence of Secretoglobin Genes in Squamate and Archosaur Reptiles that Flowered into Diversity in Mammals.Genome biology and evolution · 2025Article
- Evolutionary dynamics of the calcium/cation antiporter superfamily in Brassicaceae: codon usage, selection pressure, andFrontiers in plant science · 2025Article
- Pervasive conservation of intron number and other genetic elements revealed by a chromosome-level genomic assembly of the hyper-polymorphic nematodebioRxiv : the preprint server for biology · 2024Article
- Genome-wide identification and characterization of NBLRR genes in finger millet (Eleusine coracana L.) and their expression in response to Magnaporthe grisea infection.BMC plant biology · 2024Article
- Where the minor things are: a pan-eukaryotic survey suggests neutral processes may explain much of minor intron evolution.Nucleic acids research · 2023Article
- A novel approach to analyze the association characteristics between post-spliced introns and their corresponding mRNA.Frontiers in genetics · 2023Article
- Comprehensive analysis of 1R- and 2R-MYBs reveals novel genic and protein features, complex organisation, selective expansion and insights into evolutionary tendencies.Functional & integrative genomics · 2022Article
- Genome-wide identification, genomic organization, and expression profiling of the CONSTANS-like (COL) gene family in petunia under multiple stresses.BMC genomics · 2021Article
- Comprehensive database and evolutionary dynamics of U12-type introns.Nucleic acids research · 2020Article
- Genome-Wide Identification and Characterization of the Vacuolar HInternational journal of molecular sciences · 2019Article
- Genome-wide identification and characterization of abiotic-stress responsive SOD (superoxide dismutase) gene family in Brassica juncea and B. rapa.BMC genomics · 2019Article
- Intron retention enhances gene regulatory complexity in vertebrates.Genome biology · 2017Article
- Architecture and Distribution of Introns in Core Genes of FourG3 (Bethesda, Md.) · 2017Article
- Transcription Factor Repertoire of Necrotrophic Fungal PhytopathogenFrontiers in plant science · 2017Article
- Dramatic Number Variation of R Genes in Solanaceae Species Accounted for by a Few R Gene Subfamilies.PloS one · 2016Article
- Comprehensive Expression Profiling of Rice Tetraspanin Genes Reveals Diverse Roles During Development and Abiotic Stress.Frontiers in plant science · 2015Article
- The complex intron landscape and massive intron invasion in a picoeukaryote provides insights into intron evolution.Genome biology and evolution · 2013Article
- Evolutionary history of exon shuffling.Genetica · 2012Article
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
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3 authors.
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Abstract
backgroundThe origin of spliceosomal introns is the central subject of the introns-early versus introns-late debate. The distribution of intron phases is non-uniform, with an excess of phase-0 introns. Introns-early explains this by speculating that a fraction of present-day introns were present between minigenes in the progenote and therefore must lie in phase-0. In contrast, introns-late predicts that the nonuniformity of intron phase distribution reflects the nonrandomness of intron insertions.
resultsIn this paper, we tested the two theories using analyses of intron phase distribution. We inferred the evolution of intron phase distribution from a dataset of 684 gene orthologs from seven eukaryotes using a maximum likelihood method. We also tested whether the observed intron phase distributions from 10 eukaryotes can be explained by intron insertions on a genome-wide scale. In contrast to the prediction of introns-early, the inferred evolution of intron phase distribution showed that the proportion of phase-0 introns increased over evolution. Consistent with introns-late, the observed intron phase distributions matched those predicted by an intron insertion model quite well.
conclusionOur results strongly support the introns-late hypothesis of the origin of spliceosomal introns.
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