ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Photic regulation of arylalkylamine N-acetyltransferase binding to 14-3-3 proteins in retinal photoreceptor cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Hippocampal synaptic plasticity impairment and melatonin synthesis reduction in cognitive decline of a rodent model of Alzheimer's disease-like pathology.Pflugers Archiv : European journal of physiology · 2025Article
- Melatonin Synthesis and Function: Evolutionary History in Animals and Plants.Frontiers in endocrinology · 2019Review
- Analysis of 14-3-3 isoforms expressed in photoreceptors.Experimental eye research · 2018Article
- Daily Rhythm in Plasma N-acetyltryptamine.Journal of biological rhythms · 2017Article
- Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats.Frontiers in cellular neuroscience · 2017Article
- Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration.Progress in retinal and eye research · 2016Review
- Fundamental issues related to the origin of melatonin and melatonin isomers during evolution: relation to their biological functions.International journal of molecular sciences · 2014Review
- A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitors.Assay and drug development technologies · 2013Article
- The ubiquitin-proteasome system in retinal health and disease.Molecular neurobiology · 2013Review
- Modulation of 14-3-3/phosphotarget interaction by physiological concentrations of phosphate and glycerophosphates.PloS one · 2013Article
- N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2012Review
- Melatonin: an underappreciated player in retinal physiology and pathophysiology.Experimental eye research · 2012Review
- Monomeric 14-3-3ζ has a chaperone-like activity and is stabilized by phosphorylated HspB6.Biochemistry · 2012Article
- The hormonal Zeitgeber melatonin: role as a circadian modulator in memory processing.Frontiers in molecular neuroscience · 2012Article
- Melatonin synthesis in retina: cAMP-dependent transcriptional regulation of chicken arylalkylamine N-acetyltransferase by a CRE-like sequence and a TTATT repeat motif in the proximal promoter.Journal of neurochemistry · 2011Article
- Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors.The Journal of biological chemistry · 2011Article
- Phosphorylation of GRK7 by PKA in cone photoreceptor cells is regulated by light.Journal of neurochemistry · 2008Article
- Localization and regulation of dopamine receptor D4 expression in the adult and developing rat retina.Experimental eye research · 2008Article
- Dopamine D4 receptors regulate intracellular calcium concentration in cultured chicken cone photoreceptor cells: relationship to dopamine receptor-mediated inhibition of cAMP formation.Brain research · 2008Article
- Melatonin in Retinal Physiology and Pathology: The Case of Age-Related Macular Degeneration.Oxidative medicine and cellular longevityReview
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
14-3-3 proteins are a ubiquitous, highly conserved family of chaperone proteins involved in signal transduction, regulation of cell cycle, intracellular trafficking/targeting, cytoskeletal structure, and transcription. Although 14-3-3 proteins are among the most abundant proteins in the CNS, very little is known about their functional roles in the vertebrate retina. In the present study, we demonstrated that photoreceptors express 14-3-3 protein(s) and identified a 14-3-3 binding partner in photoreceptor cells, the melatonin-synthesizing enzyme arylalkylamine N-acetyltransferase (AANAT). Importantly, our data demonstrate that the binding of 14-3-3 to AANAT is regulated by light, with dramatic functional consequences. During the night in darkness, retinal AANAT is phosphorylated and forms a complex with 14-3-3 proteins with an apparent molecular weight of approximately 90 kDa. Phosphorylation of AANAT facilitates the binding of enzyme to 14-3-3 proteins. Within the complex, AANAT is catalytically activated and protected from dephosphorylation and degradation. Light disrupts the AANAT/14-3-3 complex, leading to catalytic inactivation, dephosphorylation, and proteolytic degradation of the enzyme. In the presence of the proteasome inhibitor, lactacystin, light results in the formation of a high molecular weight complex (>150 kDa), which may represent an intermediate in the AANAT degradation process. These findings provide new insight into the roles of 14-3-3 proteins in photoreceptor cells and to the mechanisms controlling melatonin synthesis in the vertebrate retina.
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