ArticleJournal of molecular evolution2006
Mammalian male mutation bias: impacts of generation time and regional variation in substitution rates.
Article in Journal of molecular evolution, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- Progress of sex control techniques in mammals†.Biology of reproduction · 2025Review
- Temperature dependence of spontaneous mutation rates.Genome research · 2021Article
- Pedigree-based and phylogenetic methods support surprising patterns of mutation rate and spectrum in the gray mouse lemur.Heredity · 2021Article
- Patterns of DNA variation between the autosomes, the X chromosome and the Y chromosome in Bos taurus genome.Scientific reports · 2020Article
- Evolution of Young Sex Chromosomes in Two Dioecious Sister Plant Species with Distinct Sex Determination Systems.Genome biology and evolution · 2019Article
- Repeat associated mechanisms of genome evolution and function revealed by theGenome research · 2018Article
- Multicopy gene family evolution on primate Y chromosomes.BMC genomics · 2016Article
- Recent insertion/deletion (reINDEL) mutations: increasing awareness to boost molecular-based research in ecology and evolution.Ecology and evolution · 2015Article
- Identification of two novel mutations in the PHEX gene in Chinese patients with hypophosphatemic rickets/osteomalacia.PloS one · 2014Article
- Article
- Genome analyses substantiate male mutation bias in many species.BioEssays : news and reviews in molecular, cellular and developmental biology · 2011Review
- Diversification and the rate of molecular evolution: no evidence of a link in mammals.BMC evolutionary biology · 2011Article
- The genome as a life-history character: why rate of molecular evolution varies between mammal species.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Female-to-male breeding ratio in modern humans-an analysis based on historical recombinations.American journal of human genetics · 2010Article
- Doubts about complex speciation between humans and chimpanzees.Trends in ecology & evolution · 2009Article
- Evidence that replication-associated mutation alone does not explain between-chromosome differences in substitution rates.Genome biology and evolution · 2009Article
- Mutation patterns in the human genome: more variable than expected.PLoS biology · 2009Article
- Human-macaque comparisons illuminate variation in neutral substitution rates.Genome biology · 2008Article
- Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II.Molecular and cellular biology · 2008Article
- Biased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion.Genome research · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In mammals, males undergo a greater number of germline cell divisions compared with females. Thus, the male germline accumulates more DNA replication errors, which result in male mutation bias-a higher mutation rate for males than for females. The phenomenon of male mutation bias has been investigated mostly for rodents and primates, however, it has not been studied in detail for other mammalian orders. Here we sequenced and analyzed five introns of three genes (DBX/DBY, UTX/UTY, and ZFX/ZFY) homologous between X and Y chromosomes in several species of perissodactyls (horses and rhinos) and of primates. Male mutation bias was evident: substitution rate was higher for a Y chromosome intron than for its X chromosome homologue for all five intron pairs studied. Substitution rates varied regionally among introns sequenced on the same chromosome and this variation influenced male mutation bias inferred from each intron pair. Interestingly, we observed a positive correlation in substitution rates between homologous X and homologous Y introns as well as between orthologous primate and perissodactyl introns. The male-to-female mutation rate ratio estimated from concatenated sequences of five perissodactyl introns was 3.88 (95% CI = 2.90-6.07). Using the data generated here and estimates available in the literature, we compared male mutation bias among several mammalian orders. We conclude that male mutation bias is significantly higher for organisms with long generation times (primates, perissodactyls, and felids) than for organisms with short generation times (e.g., rodents) since the former undergo a greater number of male germline cell divisions.
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