ArticleThe Journal of clinical investigation2006
Toll-like receptors and IFN-alpha: partners in autoimmunity.
Article in The Journal of clinical investigation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Corneal pain and experimental model development.Progress in retinal and eye research · 2019Review
- Increased Abundance of Plasmacytoid Dendritic Cells and Interferon-Alpha Induces Plasma Cell Differentiation in Patients of IgA Nephropathy.Mediators of inflammation · 2017Article
- Genomic profiling of host responses to Lassa virus: therapeutic potential from primate to man.Future virology · 2015Article
- Prevention or acceleration of type 1 diabetes by viruses.Cellular and molecular life sciences : CMLS · 2013Review
- Type I IFN-mediated regulation of IL-1 production in inflammatory disorders.Cellular and molecular life sciences : CMLS · 2012Review
- Characteristics of plasmacytoid dendritic cell and CD4+ T cell in HIV elite controllers.Clinical & developmental immunology · 2012Review
- Plasmacytoid dendritic cells in HIV infection: striking a delicate balance.Journal of leukocyte biology · 2010Review
- Chronic alcohol consumption generates a vulnerable immune environment during early SIV infection in rhesus macaques.Alcoholism, clinical and experimental research · 2008Article
- PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation.The Journal of experimental medicine · 2008Article
- Dendritic cells and cytokines in human inflammatory and autoimmune diseases.Cytokine & growth factor reviews · 2008Review
- Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history.Cytokine & growth factor reviews · 2008Review
- Sensing of viral infection and activation of innate immunity by toll-like receptor 3.Clinical microbiology reviews · 2008Review
- Toll-like receptors and innate immune responses in systemic lupus erythematosus.Arthritis research & therapy · 2007Article
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many autoimmune diseases are thought to be precipitated by viral infections. In this issue of the JCI, Lang et al. demonstrate that, in a mouse model of autoimmune hepatitis, viral infections not only trigger expansion of self-reactive T cells but also activate antigen-presenting cells through TLR stimulation (see the related article beginning on page 2456). Activated cells then secrete IFN-alpha and TNF-alpha, which trigger tissue release of chemokines that attract self-reactive CD8+ T cells, ultimately leading to liver damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.