ArticleAgents and actions1990
Histamine secretion from mast cells stimulated with ATP.
Article in Agents and actions, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Physiologic roles of P2 receptors in leukocytes.Journal of leukocyte biology · 2022Review
- Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness.JCI insight · 2021Article
- A single reaction-diffusion equation for the multifarious eruptions of urticaria.PLoS computational biology · 2020Article
- Purinergic Signaling in Mast Cell Degranulation and Asthma.Frontiers in pharmacology · 2017Review
- Extracellular ATP and other nucleotides-ubiquitous triggers of intercellular messenger release.Purinergic signalling · 2016Review
- The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.Purinergic signalling · 2013Article
- G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation.Immunology letters · 2007Review
- Acute paw oedema formation induced by ATP: re-evaluation of the mechanisms involved.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 1996Article
- Effects of suramin on contractions of the guinea-pig vas deferens induced by analogues of adenosine 5'-triphosphate.British journal of pharmacology · 1995Article
- Some characteristics of the ATP-induced histamine release from and permeabilization of rat mast cells.Agents and actions · 1993Article
- Zn2+ potentiates excitatory action of ATP on mammalian neurons.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Adenosine 5'-triphosphate (ATP) induced a non-cytotoxic, calcium-dependent release of histamine and prostaglandin D2 from rat serosal mast cells. The effect was tissue and species specific. In particular, tissue mast cells from the guinea pig and man were totally unresponsive. The release evoked by the nucleotide was unaffected by antiasthmatic chromones but was inhibited by structurally related flavonoids and by cAMP-active drugs. Secretion was blocked both by the P2Y-purinoceptor antagonist reactive blue 2 and the P2X-antagonist suramin, whereas the P2-agonists 2-methylthio ATP, alpha, beta- and beta, gamma-methylene ATP were inactive. These findings indicate that ATP acts through a novel purinoceptor or binding site which is present on certain types of mast cells.
Indexed as
Identifiers
1695463What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.