ArticleJournal of molecular neuroscience : MN2006
The dynamic instability of microtubules is required for aggresome formation in oligodendroglial cells after proteolytic stress.
Article in Journal of molecular neuroscience : MN, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Attaching and effacing pathogens modulate host mitochondrial structure and function.International review of cell and molecular biology · 2023Review
- Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibition.Cell death & disease · 2022Article
- Aggresome assembly at the centrosome is driven by CP110-CEP97-CEP290 and centriolar satellites.Nature cell biology · 2022Article
- Melatonin Prevents the Harmful Effects of Obesity on the Brain, Including at the Behavioral Level.Molecular neurobiology · 2018Article
- A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.Journal of cell science · 2017Article
- On the nature of the Cu-rich aggregates in brain astrocytes.Redox biology · 2017Article
- ADNP/ADNP2 expression in oligodendrocytes: implication for myelin-related neurodevelopment.Journal of molecular neuroscience : MN · 2015Article
- Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance.Journal of molecular neuroscience : MN · 2015Article
- Activation of autophagy by rapamycin does not protect oligodendrocytes against protein aggregate formation and cell death induced by proteasomal inhibition.Journal of molecular neuroscience : MN · 2015Article
- Novel roles for α-crystallins in retinal function and disease.Progress in retinal and eye research · 2012Review
- Recruitment of the oncoprotein v-ErbA to aggresomes.Molecular and cellular endocrinology · 2011Article
- Dynamic subunit exchange and the regulation of microtubule assembly by the stress response protein human alphaB crystallin.PloS one · 2010Article
- The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration.International journal of cell biology · 2010Article
- Significant roles of microtubules in mature striated muscle deduced from the correlation between tubulin and its molecular chaperone alphaB-crystallin in rat muscles.The journal of physiological sciences : JPS · 2009Article
- Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone.Journal of neuroscience research · 2008Article
- The cytoskeleton in oligodendrocytes. Microtubule dynamics in health and disease.Journal of molecular neuroscience : MN · 2008Review
- Interactive domains in the molecular chaperone human alphaB crystallin modulate microtubule assembly and disassembly.PloS one · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
University of Oldenburg, Department of Biology, Molecular Neurobiology, D-26111 Oldenburg, Germany Ubiquitinated tau-positive inclusion bodies in oligodendrocytes are consistent features in a variety of neurodegenerative disorders, and their formation points to an underlying incapacity of the protein quality control system that normally prevents the accumulation of misfolded proteins. To study the consequences of proteasomal impairment, we have used an oligodendroglial cell line, namely OLN-t40 cells, genetically engineered to express the longest human tau isoform. Treatment of OLN-t40 cells with the proteasomal inhibitor MG-132 (0.5 microM, 18 h) caused the formation of large, nonfibrillary tau-positive aggregates containing the small HSP alphaB-crystallin and ubiquitin in the vicinity of the microtubule organizing center (MTOC). The sequestration of misfolded proteins into specialized regions, called aggresomes, in response to stress stimuli has been reported to be associated with a redistribution of intermediate filaments (IFs). In oligodendroglial cells, which do not contain a cytoplasmic IF system, aggresomelike inclusions were instead surrounded by bundles of MTs and contained clusters of mitochondria. Aggresome formation was prevented by both MT-stabilizing and -destabilizing drugs, indicating not only that an intact cytoskeleton but also the dynamic instability of the MT network is required. Furthermore, the binding of stress-induced alphaBcrystallin to the MTs points to a possible protective role during disease progression.
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