ArticleMolecular and cellular biology2006
A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 63 citations in OpenAlex.
- A novel role for the E2F transcription factor and the ER stress sensor IRE1 in cytoplasmic DNA accumulation.Genetics · 2025Article
- Clinical and genetic characterization of a progressive RBL2-associated neurodevelopmental disorder.Brain : a journal of neurology · 2025Article
- Wnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathway.PLoS biology · 2024Article
- The histone demethylase Kdm5 controls Hid-induced cell death inFrontiers in cell death · 2024Article
- NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways.PLoS genetics · 2020Article
- Single cell RNA-sequencing identifies a metabolic aspect of apoptosis in Rbf mutant.Nature communications · 2018Article
- Cancer-testis specific gene OIP5: a downstream gene of E2F1 that promotes tumorigenesis and metastasis in glioblastoma by stabilizing E2F1 signaling.Neuro-oncology · 2018Article
- An alternatively spliced form affecting the Marked Box domain of Drosophila E2F1 is required for proper cell cycle regulation.PLoS genetics · 2018Article
- Learning on the Fly: The Interplay between Caspases and Cancer.BioMed research international · 2018Review
- Different cell cycle modifications repress apoptosis at different steps independent of developmental signaling in Drosophila.Molecular biology of the cell · 2016Article
- Transcriptome dynamics in the asexual cycle of the chordate Botryllus schlosseri.BMC genomics · 2016Article
- Regulation of cell polarity determinants by the Retinoblastoma tumor suppressor protein.Scientific reports · 2016Article
- Novel regulation and functional interaction of polycistronic miRNAs.RNA (New York, N.Y.) · 2016Article
- POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation.Nature communications · 2015Article
- Drosophila as a Potential Model for Ocular Tumors.Ocular oncology and pathology · 2015Review
- Cell death in development: Signaling pathways and core mechanisms.Seminars in cell & developmental biology · 2015Review
- Role of Drosophila retinoblastoma protein instability element in cell growth and proliferation.Cell cycle (Georgetown, Tex.) · 2015Article
- dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes.Nucleic acids research · 2014Article
- An intronic microRNA links Rb/E2F and EGFR signaling.PLoS genetics · 2014Article
- Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities.PLoS genetics · 2014Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The inactivation of retinoblastoma (Rb) family members sensitizes cells to apoptosis. This cell death affects the development of mutant animals and also provides a critical constraint to the malignant potential of Rb mutant tumor cells. The extent of apoptosis caused by the inactivation of Rb is highly cell type and tissue specific, but the underlying reasons for this variation are poorly understood. Here, we characterize a specific time and place during Drosophila melanogaster development where rbf1 mutant cells are exquisitely sensitive to apoptosis. During the third larval instar, many rbf1 mutant cells undergo E2F-dependent cell death in the morphogenetic furrow. Surprisingly, this pattern of apoptosis is not caused by inappropriate cell cycle progression but instead involves the action of Argos, a secreted protein that negatively regulates Drosophila epidermal growth factor receptor (EGFR [DER]) activity. Apoptosis of rbf1 mutant cells is suppressed by the activation of DER, ras, or raf or by the inactivation of argos, sprouty, or gap1, and inhibition of DER strongly enhances apoptosis in rbf1 mutant discs. We show that RBF1 and a DER/ras/raf signaling pathway cooperate in vivo to suppress E2F-dependent apoptosis and that the loss of RBF1 alters a normal program of cell death that is controlled by Argos and DER. These results demonstrate that a gradient of DER/ras/raf signaling that occurs naturally during development provides the contextual signals that determine when and where the inactivation of rbf1 results in dE2F1-dependent apoptosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.