ArticleMolecular and cellular biology2006
Specific differentially methylated domain sequences direct the maintenance of methylation at imprinted genes.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- A new class of human CpG Island promoters with primate-specific repeats.Scientific reports · 2025Article
- Transient DNMT1 suppression reveals hidden heritable marks in the genome.Nucleic acids research · 2015Article
- The DNMT1 intrinsically disordered domain regulates genomic methylation during development.Genetics · 2015Article
- Partial Loss of Genomic Imprinting Reveals Important Roles for Kcnq1 and Peg10 Imprinted Domains in Placental Development.PloS one · 2015Article
- A downstream CpG island controls transcript initiation and elongation and the methylation state of the imprinted Airn macro ncRNA promoter.PLoS genetics · 2012Article
- Dynamic CpG island methylation landscape in oocytes and preimplantation embryos.Nature genetics · 2011Article
- Distinct roles of DMAP1 in mouse development.Molecular and cellular biology · 2011Article
- Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes.Development (Cambridge, England) · 2011Article
- Methylation profiling in individuals with uniparental disomy identifies novel differentially methylated regions on chromosome 15.Genome research · 2010Article
- Identification of a region of the DNMT1 methyltransferase that regulates the maintenance of genomic imprints.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Epigenetic profiling at mouse imprinted gene clusters reveals novel epigenetic and genetic features at differentially methylated regions.Genome research · 2009Article
- The function of non-coding RNAs in genomic imprinting.Development (Cambridge, England) · 2009Review
- Transcription is required for establishment of germline methylation marks at imprinted genes.Genes & development · 2009Article
- DNA methyltransferase 1o functions during preimplantation development to preclude a profound level of epigenetic variation.Developmental biology · 2008Article
- Signaling silence--breaking ground and spreading out.Genes & development · 2008Article
- Article
- Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing.Genes & development · 2007Article
- Article
- Chromatin mechanisms in genomic imprinting.Mammalian genome : official journal of the International Mammalian Genome SocietyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Landmark features of imprinted genes are differentially methylated domains (DMDs), in which one parental allele is methylated on CpG dinucleotides and the opposite allele is unmethylated. Genetic experiments in the mouse have shown that DMDs are required for the parent-specific expression of linked clusters of imprinted genes. To understand the mechanism whereby the differential methylation is established and maintained, we analyzed a series of transgenes containing DMD sequences and showed that imperfect tandem repeats from DMDs associated with the Snurf/Snrpn, Kcnq1, and Igf2r gene clusters govern transgene imprinting. For the Igf2r DMD the minimal imprinting signal is two unit copies of the tandem repeat. This imprinted transgene behaves identically to endogenous imprinted genes in Dnmt1o and Dnmt3L mutant mouse backgrounds. The primary function of the imprinting signal within the transgene DMD is to maintain, during embryogenesis and a critical period of genomic reprogramming, parent-specific DNA methylation states established in the germ line. This work advances our understanding of the imprinting mechanism by defining a genomic signal that dependably perpetuates an epigenetic state during postzygotic development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.