Evidence map›Paper›PMID 16954278›Full record

ArticleJournal of clinical microbiology2006

Molecular differentiation of Treponema pallidum subspecies.

Arturo Centurion-Lara, Barbara J Molini, Charmie Godornes, Eileen Sun, Karin Hevner, Wesley C Van Voorhis, Sheila A Lukehart

Abstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. [Evolution of treatment of syphilis through history].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. When is syphilis not syphilis? Or is it?Sexually transmitted diseases · 2014
    Article
  12. Current trends in donor testing to detect syphilis infection.Current infectious disease reports · 2014
    Article
  13. The endemic treponematoses.Clinical microbiology reviews · 2014
    Review
  14. Article
  15. Review
  16. Article
  17. Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2012
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Arturo Centurion-LaraDepartment of Medicine, University of Washington, Seattle, 98195, USA. acentur@u.washington.edu
Barbara J Molini
Charmie Godornes
Eileen Sun
Karin Hevner
Wesley C Van Voorhis
Sheila A Lukehart
University of Washington · US

Funding

VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
TREPONEMA PALLIDUM PATHOGENESIS ASSOCIATED MOLECULESR01AI042143 · NIAID · UNIVERSITY OF WASHINGTON · PI LUKEHART, SHEILA A. · 1998 to 2015
$5.4M
Project 4: Antigenic variation of TprKR01AI063940 · NIAID · UNIVERSITY OF WASHINGTON · PI LUKEHART, SHEILA A. · 2004 to 2013
$3.3M
PROTECTIVE IMMUNITY AGAINST SYPHILISP01AI034616 · NIAID · UNIVERSITY OF WASHINGTON · PI LUKEHART, SHEILA A. · 1993 to 2003
$2.5M
NIAID NIH HHS AI34616NIAID NIH HHS AI42143NIAID NIH HHS AI63940NIAID NIH HHS P01 AI034616NIAID NIH HHS R01 AI042143NIAID NIH HHS R01 AI063940NIAID NIH HHS T32 AI007140
6 · The paper itself

Abstract

Treponema pallidum includes three subspecies of antigenically highly related treponemes. These organisms cause clinically distinct diseases and cannot be distinguished by any existing test. In this report, genetic signatures are identified in two tpr genes which, in combination with the previously published signature in the 5' flanking region of the tpp15 gene, can differentiate the T. pallidum subspecies, as well as a simian treponeme.

Indexed as

AnimalsBacterial Outer Membrane ProteinsBacterial Typing TechniquesBase SequenceDNA, BacterialHumansMolecular Sequence DataPolymorphism, Restriction Fragment LengthRabbitsSpecies SpecificitySyphilisTreponemal InfectionsTreponema pallidumBacterial Outer Membrane ProteinsDNA, BacterialTpr protein, Treponema

Identifiers

PMID16954278
PMCPMC1594706
OpenAlexW2139731381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.