ArticleProceedings of the National Academy of Sciences of the United States of America2006
A malleable catalyst dominates the metabolism of drugs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- A Computational Pipeline Observes the Flexibility and Dynamics of Plant Cytochrome P450 Binding Sites.International journal of molecular sciences · 2024Article
- Characterization of Interactions Among CYP1A2, CYP2B4, and NADPH-cytochrome P450 Reductase: Identification of Specific Protein Complexes.Drug metabolism and disposition: the biological fate of chemicals · 2018Article
- 7,8-benzoflavone binding to human cytochrome P450 3A4 reveals complex fluorescence quenching, suggesting binding at multiple protein sites.Journal of biomolecular structure & dynamics · 2018Article
- Structural insights on bioremediation of polycyclic aromatic hydrocarbons using microalgae: a modelling-based computational study.Environmental monitoring and assessment · 2018Article
- Physical Studies of P450-P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures.Frontiers in pharmacology · 2017Review
- The functional effects of physical interactions involving cytochromes P450: putative mechanisms of action and the extent of these effects in biological membranes.Drug metabolism reviews · 2016Review
- Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation.PloS one · 2015Article
- CYP 2D6 binding affinity predictions using multiple ligand and protein conformations.International journal of molecular sciences · 2013Article
- Article
- Rationalization of stereospecific binding of propranolol to cytochrome P450 2D6 by free energy calculations.European biophysics journal : EBJ · 2012Article
- Defining CYP3A4 structural responses to substrate binding. Raman spectroscopic studies of a nanodisc-incorporated mammalian cytochrome P450.Journal of the American Chemical Society · 2011Article
- Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency.European journal of endocrinology · 2010Article
- QM/MM Simulation on P450 BM3 Enzyme Catalysis Mechanism.Journal of chemical theory and computation · 2009Article
- Substrate binding to cytochromes P450.Analytical and bioanalytical chemistry · 2008Review
- Magic-angle spinning solid-state NMR spectroscopy of nanodisc-embedded human CYP3A4.Biochemistry · 2007Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.