ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2006
The safety and adequacy of antithrombotic therapy for atrial fibrillation: a regional cohort study.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Effectiveness and patient safety of platelet aggregation inhibitors in the prevention of cardiovascular disease and ischemic stroke in older adults - a systematic review.BMC geriatrics · 2017Pooled it
- Pooled it
- Measures of vitamin K antagonist control reported in atrial fibrillation and venous thromboembolism studies: a systematic review.BMJ open · 2014Pooled it
- Systematic review of observational studies assessing bleeding risk in patients with atrial fibrillation not using anticoagulants.PloS one · 2014Pooled it
- Performance of stroke risk scores in older people with atrial fibrillation not taking warfarin: comparative cohort study from BAFTA trial.BMJ (Clinical research ed.) · 2011Trial
- Practice nursed-based, individual and video-assisted patient education in oral anticoagulation--protocol of a cluster-randomized controlled trial.BMC family practice · 2011Trial
- Atrial Fibrillation in Older People: Concepts and Controversies.Frontiers in medicine · 2019Review
- [Prevalence of oral anticoagulation and quality of its management in primary healthcare: A study by the Health Sentinel Network of the Region of Valencia (Spain)].Atencion primaria · 2017Observational
- Quality of vitamin K antagonist control and outcomes in atrial fibrillation patients: a meta-analysis and meta-regression.Thrombosis journal · 2014Article
- Potential impact of new oral anticoagulants on the management of atrial fibrillation-related stroke in primary care.International journal of clinical practice · 2013Review
- Warfarin for atrial fibrillation.The British journal of general practice : the journal of the Royal College of General Practitioners · 2006Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAtrial fibrillation is a common problem in older people. The evidence base for the safety of warfarin and aspirin in atrial fibrillation is largely derived from selective research studies and secondary care. Further assessment of the safety of warfarin in older people with atrial fibrillation in routine primary care is needed.
aimTo measure the complication rates and adequacy of warfarin control in a cohort of patients with atrial fibrillation managed in primary care and compare them with published data from controlled trials and community patients with atrial fibrillation not receiving warfarin. DESIGN OF STUDY: Retrospective review of regional cohort.
settingTwenty-seven general practices in southwest Scotland.
methodCase note review of 601 patients previously identified as having atrial fibrillation by GPs.
resultsThe average age of our cohort was 77 years at recruitment. Two hundred and sixty-four (44%) patients died within 5 years of follow up. Three hundred and nine of the 601 (51%) patients with atrial fibrillation took warfarin at some stage during this study. INR (international normalised ratio) was maintained between 2 and 3 for 68% of the time. Bleeding risk was higher in patients taking warfarin than in those on aspirin or no antithrombotic therapy (warfarin 9.0% per year versus aspirin 4.7% per year versus no therapy 4.6% per year). The annual risk of any bleeding complication on warfarin (9%) was similar to that recorded in randomised trials (9.2%) whereas the annual risk of severe bleeding was approximately double (2.6 versus 1.3%).
conclusionAdequacy of anticoagulant control was broadly comparable to that reported in clinical trials, whereas the risk of severe bleeding was higher, possibly reflecting the older age and the comorbidities of our unselected cohort.
Indexed as
Identifiers
16954003PMC1876637W1729190912What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.