ArticleParasitology research2007
Immunocompetence does not correlate with resistance to helminth parasites in house mouse subspecies and their hybrids.
Article in Parasitology research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Application of Concanavalin A during immune responsiveness skin-swelling tests facilitates measurement interpretation in mammalian ecology.Ecology and evolution · 2016Article
- Article
- What are carotenoids signaling? Immunostimulatory effects of dietary vitamin E, but not of carotenoids, in Iberian green lizards.Die Naturwissenschaften · 2014Article
- Histological assessment of cellular immune response to the phytohemagglutinin skin test in Brazilian free-tailed bats (Tadarida brasiliensis).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2010Article
- Variation in immune defence among populations of Gammarus pulex (Crustacea: Amphipoda).Oecologia · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A central point not yet elucidated in immuno-ecological studies is whether the different ways to assess the immune status of individuals are good indicators of parasite resistance of the host. We investigate the relationship between immunocompetence and the resistance/susceptibility phenotype of five strains of two European subspecies of the house mouse and their hybrids derived from natural populations. The assessment of immunocompetence was measured indirectly by the mass of the spleen and directly by the phytohaemagglutinin (PHA) test. The resistance of each mouse strain to common helminths was previously determined by the distribution of parasite burdens obtained after experimental infection. We found no relationship between the resistance/susceptibility phenotype of strains and the level of PHA response or the size of the spleen. A significant negative correlation was found between residuals of log spleen mass (controlled for body mass) and PHA response, suggesting that these two components of immune function are not independent measures of defence against parasitism. We discuss the validity of these two techniques of measuring immunocompetence and emphasize the importance of taking into account the complexity of the immune system at structural and functional levels in understanding the component of selection attributable to parasitism in the evolution of immunocompetence.
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Registered trials
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