ArticlePflugers Archiv : European journal of physiology2006
Rho-kinase-mediated regulation of receptor-agonist-stimulated smooth muscle contraction.
Article in Pflugers Archiv : European journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 73 citations in OpenAlex.
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- The Effect of Luteolin on the Modulation of Vascular Contractility via ROCK and CPI-17 Inactivation.Biomolecules & therapeutics · 2023Article
- Epoxyeicosatrienoic Acid and Prostanoid Crosstalk at the Receptor and Intracellular Signaling Levels to Maintain Vascular Tone.International journal of molecular sciences · 2022Article
- The Effect of Galangin on the Regulation of Vascular Contractility via the Holoenzyme Reactivation Suppressing ROCK/CPI-17 rather than PKC/CPI-17.Biomolecules & therapeutics · 2022Article
- AdipoRon, adiponectin receptor agonist, improves vascular function in the mesenteric arteries of type 2 diabetic mice.PloS one · 2020Article
- Exaggerated blood pressure response to fasudil or nifedipine in hypertensive Ren-2 transgenic rats: role of altered baroreflex.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Atorvastatin ameliorates the contractile dysfunction of the aorta induced by organ culture.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Endothelium Independent Effect of Pelargonidin on Vasoconstriction in Rat Aorta.Biomolecules & therapeutics · 2018Article
- Hypothermia Inhibits Endothelium-Independent Vascular Contractility via Rho-kinase Inhibition.Biomolecules & therapeutics · 2018Article
- Characterization of pressure-mediated vascular tone in resistance arteries from bile duct-ligated rats.Oncotarget · 2017Article
- Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension.BioMed research international · 2017Article
- Endothelium-Independent Effect of Fisetin on the Agonist-Induced Regulation of Vascular Contractility.Biomolecules & therapeutics · 2016Article
- Cardamonin inhibits agonist-induced vascular contractility via Rho-kinase and MEK inhibition.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Article
- The inhibitory effect of shikonin on the agonist-induced regulation of vascular contractility.Biomolecules & therapeutics · 2015Article
- Pericytes, microvasular dysfunction, and chronic rejection.Transplantation · 2015Review
- A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.Science signaling · 2015Article
- Induction of oligodendrocyte differentiation and in vitro myelination by inhibition of rho-associated kinase.ASN neuro · 2014Article
- The Inhibitory Effect of Apigenin on the Agonist-Induced Regulation of Vascular Contractility via Calcium Desensitization-Related Pathways.Biomolecules & therapeutics · 2014Article
- Cerebral artery alpha-1 AR subtypes: high altitude long-term acclimatization responses.PloS one · 2014Article
- The inhibitory effect of eupatilin on the agonist-induced regulation of vascular contractility.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
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2 authors at 1 institution in 1 country.
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Abstract
Rho kinase was shown to regulate smooth muscle contraction through modulating myosin phosphatase (MLCP) activity, but the in vivo mechanism remains to be clarified. This study examined the effects of Rho kinase inhibition on the phosphorylation time course of MLCP subunit MYPT1 at Thr697 and Thr855 and MLCP inhibitory protein CPI-17 at Thr38 and on actin polymerization during the contraction of rat tail artery (RTA) smooth muscle. Rho kinase inhibitor Y27632 suppressed force activated by alpha(1)-adrenergic agonist phenylephrine or thromboxane A(2) analog U46619 with concomitant decreases in MLC(20) phosphorylation. Phenylephrine and U46619 significantly increased MYPT1(Thr855) phosphorylation that was eliminated by Y27632 pretreatment, whereas MYPT1(Thr697) phosphorylation was not stimulated. Phenylephrine increased CPI-17(Thr38) phosphorylation that was not inhibited by Y27632 but was abolished by a protein kinase C inhibitor Ro 31-8220; in contrast, U46619 did not stimulate CPI-17 phosphorylation. Both agonists increased actin polymerization that was diminished by Y27632 under phenylephrine but not U46619 activation. These results demonstrated a temporal correlation between MYPT1(Thr855) phosphorylation, MLC(20) phosphorylation, and contraction in a Rho-kinase-dependent manner for both phenylephrine and U46619 stimulation, suggesting that Rho kinase regulates MLCP activity through MYPT1(Thr855) phosphorylation during RTA smooth muscle contraction. Furthermore, Rho kinase regulates actin polymerization activated by alpha(1)-adrenoceptors but is less significant in thromboxane receptor stimulation.
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