ArticleMolecular and cellular biology1990
The Wnt-1 (int-1) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumor virus.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- β-catenin in adrenal zonation and disease.Molecular and cellular endocrinology · 2021Review
- MicroRNA regulation of liver cancer stem cells.American journal of cancer research · 2018Review
- Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation.Oncotarget · 2016Article
- Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling.Oncotarget · 2015Article
- Inhibition of cancer cell migration and invasion through suppressing the Wnt1-mediating signal pathway by G-quadruplex structure stabilizers.The Journal of biological chemistry · 2014Article
- Low-density lipoprotein receptor-related protein 6 (LRP6) rs10845498 polymorphism is associated with a decreased risk of non-small cell lung cancer.International journal of medical sciences · 2014Article
- Wnt-signalling in the embryonic mammary gland.Journal of mammary gland biology and neoplasia · 2013Review
- Article
- The gold (III) porphyrin complex, gold-2a, suppresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1.American journal of translational research · 2011Article
- Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells.Cancer science · 2003Article
- Wnt signaling and mammary tumorigenesis.Journal of mammary gland biology and neoplasia · 2001Review
- Review
- The promoter of the Xwnt-5C gene contains octamer and AP-2 motifs functional in Xenopus embryos.Nucleic acids research · 1994Article
- Activation of the mouse mdr3 gene by insertion of retroviruses in multidrug-resistant P388 tumor cells.Molecular and cellular biology · 1993Article
- Wnt-1-inducing factor-1: a novel G/C box-binding transcription factor regulating the expression of Wnt-1 during neuroectodermal differentiation.Molecular and cellular biology · 1993Article
- A mouse mammary tumor virus mammary gland enhancer confers tissue-specific but not lactation-dependent expression in transgenic mice.Journal of virology · 1992Article
- Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice.Molecular and cellular biology · 1992Article
- Two regions of the mouse mammary tumor virus long terminal repeat regulate the activity of its promoter in mammary cell lines.Molecular and cellular biology · 1991Article
- Genomic structure and restricted neural expression of the zebrafish wnt-1 (int-1) gene.The EMBO journal · 1991Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wnt-1 (int-1) is a cellular oncogene often activated by insertion of proviral DNA of the mouse mammary tumor virus. We have mapped the 5' end and the promoter area of the Wnt-1 gene by nuclease protection and primer extension assays. In differentiating P19 embryonal carcinoma cells, in which Wnt-1 is naturally expressed, two start sites of transcription were found, one preceded by two TATA boxes and one preceded by several GC boxes. In P19 cells, a 1-kilobase upstream sequence of Wnt-1 was able to confer differentiation-specific expression on a heterologous gene. We have investigated how Wnt-1 transcription was affected by mouse mammary tumor virus proviral integrations in various configurations near the promoters of the gene. One provirus has been inserted in the 5' nontranslated part of Wnt-1, in the same transcriptional orientation, and has functionally replaced the Wnt-1 promoters. Wnt-1 transcription in this tumor starts in the right long terminal repeat of the provirus, with considerable readthrough transcription from the left long terminal repeat. Another provirus has been inserted in the orientation opposite that of Wnt-1 into a GC box, disrupting the first Wnt-1 transcription start site but not the downstream start site. Most insertions have not structurally altered the Wnt-1 transcripts and have enhanced the activity of the normal two promoters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.