ArticleBritish journal of pharmacology2006
Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages.
Article in British journal of pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00147017 (Regulation of the Release of Inflammatory Mediators From Lung Macrophages.), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Regulation of the Release of Inflammatory Mediators From Lung Macrophages.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics.Cell communication and signaling : CCS · 2023Pooled it
- From Cytokines to Biomarkers: Mapping the Immunopathology of Inflammatory Bowel Disease.Cells · 2025Review
- Strategies for Improving Photodynamic Therapy Through Pharmacological Modulation of the Immediate Early Stress Response.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Aqueous Extract from Leaves ofPlants (Basel, Switzerland) · 2021Article
- p38 Inhibition Ameliorates Inspiratory Resistive Breathing-Induced Pulmonary Inflammation.Inflammation · 2018Article
- Oxidants induce a corticosteroid-insensitive phosphorylation of histone 3 at serine 10 in monocytes.PloS one · 2015Article
- Novel function for the p38-MK2 signaling pathway in circulating CD1c+ (BDCA-1+) myeloid dendritic cells from healthy donors and advanced cancer patients; inhibition of p38 enhances IL-12 whilst suppressing IL-10.International journal of cancer · 2014Article
- Activity of sputum p38 MAPK is correlated with airway inflammation and reduced FEV1 in COPD patients.Medical science monitor : international medical journal of experimental and clinical research · 2013Article
- Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function.Molecular and cellular biology · 2013Article
- New anti-inflammatory targets for chronic obstructive pulmonary disease.Nature reviews. Drug discovery · 2013Review
- Evaluation of glucocorticoid receptor function in COPD lung macrophages using beclomethasone-17-monopropionate.PloS one · 2013Article
- Comparison of the anti-inflammatory effects of Cilomilast, Budesonide and a p38 Mitogen activated protein kinase inhibitor in COPD lung tissue macrophages.BMC pharmacology & toxicology · 2012Article
- Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart Transplantation.Journal of transplantation · 2012Article
- Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-{gamma} sumoylation, and HIF-1{alpha}.The Journal of biological chemistry · 2011Article
- Endothelial and macrophage-specific deficiency of P38α MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice.PloS one · 2011Article
- Glucocorticoid insensitivity as a future target of therapy for chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2010Review
- Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1beta-stimulated human chondrocytes.British journal of pharmacology · 2010Article
- Review
- P38alpha-selective mitogen-activated protein kinase inhibitor for improvement of cultured human islet recovery.Pancreas · 2010Article
- Chronic obstructive pulmonary disease: an update of treatment related to frequently associated comorbidities.Therapeutic advances in chronic disease · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeMacrophages release cytokines that may contribute to pulmonary inflammation in conditions such as chronic obstructive pulmonary disease. Thus, inhibition of macrophage cytokine production may have therapeutic benefit. p38 MAPK may regulate cytokine production, therefore, the effect of two p38 MAPK inhibitors, SB239063 and SD-282, on the release of TNF-alpha, GM-CSF and IL-8 from human macrophages was investigated. EXPERIMENTAL APPROACH: Cytokine release was measured by ELISA. Immunoblots and mRNA expression studies were performed to confirm p38 MAPK isoform expression and activity. Macrophages were isolated from lung tissue of current smokers, ex-smokers and emphysema patients and exposed to lipopolysaccharide. These cells then released cytokines in a concentration-dependent manner. KEY
resultsSB239063 only inhibited TNF-alpha release (EC50 0.3 +/- 0.1 microM). Disease status had no effect on the efficacy of SB239063. SD-282 inhibited both TNF-alpha and GM-CSF release from macrophages (EC50 6.1 +/- 1.4 nM and 1.8 +/- 0.6 microM respectively) but had no effect on IL-8 release. In contrast, both inhibitors suppressed cytokine production in monocytes. CONCLUSIONS AND IMPLICATIONS: The differential effects of p38 MAPK inhibitors between macrophages and monocytes could not be explained by differences in p38 MAPK isoform expression or activity. However, the stability of TNF-alpha mRNA was significantly increased in macrophages compared to monocytes. These data suggest a differential involvement for p38 MAPK in macrophage cytokine production compared with monocytes. These effects are not due to lack of p38 activation or p38alpha expression in macrophages but may reflect differential effects on the stability of cytokine mRNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.