ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2006
Genetic determination and correlation of body weight and body mass index (BMI) and cross-sectional geometric parameters of the femoral neck.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Article
- Similarities in acquired factors related to postmenopausal osteoporosis and sarcopenia.Journal of osteoporosis · 2011Article
- The differences of femoral neck geometric parameters: effects of age, gender and race.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Article
- Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- Association analyses of vitamin D-binding protein gene with compression strength index variation in Caucasian nuclear families.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Article
- Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians.Calcified tissue international · 2009Article
- Association between myostatin gene polymorphisms and peak BMD variation in Chinese nuclear families.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008Article
- Bivariate linkage study of proximal hip geometry and body size indices: the Framingham study.Calcified tissue international · 2007Article
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5 authors.
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Abstract
introductionThis study aimed to examine the genetic determination of body weight, body mass index (BMI) and cross-sectional geometric parameters of the femoral neck including cross-sectional area (CSA), cortical thickness (CT), sectional modulus (Z), and buckling ratio (BR), and to test the genetic correlation between body weight/BMI and the femoral neck geometric parameters.
methodsA total of 929 healthy subjects from 292 Chinese nuclear families was included. Femoral neck geometric parameters were estimated from bone mineral density (BMD) and bone area which were measured by dual energy X-ray absorptiometry (DXA).
resultsThe heritability (h(2)) estimate values were 0.643, 0.626, 0.626, 0.674, 0.405, and 0.615 for body weight, BMI, CSA, CT, Z, and BR, respectively. Body weight was significantly correlated with bone geometric parameters (p</=0.001) with genetic correlation (rho(G)) values of 0.551, 0.457, 0.571, and -0.385, and bivariate heritability (rho2G) values of 0.304, 0.209, 0.326, and 0.148 for CSA, CT, Z, and BR, respectively. Similar correlations (p</=0.001) were observed between BMI and bone geometric parameters, with rho(G) values of 0.446, 0.432, 0.334, and -0.362, and (rho2G) values of 0.199, 0.187, 0.112, and 0.131 for CSA, CT, Z, and BR, respectively.
conclusionIn summary, our study suggested that body weight, BMI, and femoral neck geometry were under strong genetic determination. The strong genetic correlations suggested that the genetic factors of bone geometry may be overlapped with those of body weight and BMI.
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