ArticleEvidence-based complementary and alternative medicine : eCAM2006
American ginseng stimulates insulin production and prevents apoptosis through regulation of uncoupling protein-2 in cultured beta cells.
Article in Evidence-based complementary and alternative medicine : eCAM, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 71 citations in OpenAlex.
- Co-administration of viscous fiber, Salba-chia and ginseng on glycemic management in type 2 diabetes: a double-blind randomized controlled trial.European journal of nutrition · 2021Trial
- 'Oxidative stress'-A new target in the management of diabetes mellitus.Journal of family medicine and primary care · 2023Review
- Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury.International journal of molecular sciences · 2023Article
- Study on the mechanism of American ginseng extract for treating type 2 diabetes mellitus based on metabolomics.Frontiers in pharmacology · 2022Article
- Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts: a functional comparison of different extraction solvents.Journal of ginseng research · 2019Article
- Natural approaches in metabolic syndrome management.Archives of medical science : AMS · 2018Article
- MechanisticPharmacognosy magazine · 2018Article
- Chronic saponin treatment attenuates damage to the pancreas in chronic alcohol-treated diabetic rats.Journal of ginseng research · 2017Article
- Article
- EFFECTS OF GINSENG AND ITS FOUR PURIFED GINSENOSIDES (Rb2, Re, Rg1, Rd) ON HUMAN PANCREATIC ISLET β CELL IN VITRO.European journal pharmaceutical and medical research · 2016Article
- Ancient records and modern research on the mechanisms of chinese herbal medicines in the treatment of diabetes mellitus.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Plant-Derived Compounds Targeting Pancreatic Beta Cells for the Treatment of Diabetes.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Dietary coconut kernel protein beneficially modulates NFκB and RAGE expression in streptozotocin induced diabetes in rats.Journal of food science and technology · 2014Article
- Comparative study of antidiabetic activity of Cajanus cajan and Tamarindus indica in alloxan-induced diabetic mice with a reference to in vitro antioxidant activity.Pharmacognosy research · 2014Article
- Cytoprotective effect of American ginseng in a rat ethanol gastric ulcer model.Molecules (Basel, Switzerland) · 2013Article
- The role of uncoupling proteins in diabetes mellitus.Journal of diabetes research · 2013Review
- Botanical compounds: effects on major eye diseases.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Processed Panax ginseng, Sun Ginseng, Decreases Oxidative Damage Induced by tert-butyl Hydroperoxide via Regulation of Antioxidant Enzyme and Anti-apoptotic Molecules in HepG2 Cells.Journal of ginseng research · 2012Article
- Oreocnide integrifolia Flavonoids Augment Reprogramming for Islet Neogenesis and β-Cell Regeneration in Pancreatectomized BALB/c Mice.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Ginseng and diabetes: the evidences from in vitro, animal and human studies.Journal of ginseng research · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
American ginseng root displays the ability to achieve glucose homeostasis both experimentally and clinically but the unknown mechanism used by ginseng to achieve its therapeutic effects on diabetes limits its application. Disruption in the insulin secretion of pancreatic beta cells is considered the major cause of diabetes. A mitochondrial protein, uncoupling protein-2 (UCP-2) has been found to play a critical role in insulin synthesis and beta cell survival. Our preliminary studies found that the extracts of American ginseng inhibit UCP-2 expression which may contribute to the ability of ginseng protecting beta cell death and improving insulin synthesis. Therefore, we hypothesized that ginseng extracts suppress UCP-2 in the mitochondria of pancreatic beta cells, promoting insulin synthesis and anti-apoptosis (a programmed cell-death mechanism). To test the hypothesis, the serum-deprived quiescent beta cells were cultured with or without interleukin-1beta (IL-1beta), (200 pg ml(-1), a cytokine to induce beta cell apoptosis) and water extracts of American ginseng (25 mug per 5 mul administered to wells of 0.5 ml culture) for 24 h. We evaluated effects of ginseng on UCP-2 expression, insulin production, anti-/pro-apoptotic factors Bcl-2/caspase-9 expression and cellular ATP levels. We found that ginseng suppresses UCP-2, down-regulates caspase-9 while increasing ATP and insulin production/secretion and up-regulates Bcl-2, reducing apoptosis. These findings suggest that stimulation of insulin production and prevention of beta cell loss by American ginseng extracts can occur via the inhibition of mitochondrial UCP-2, resulting in increase in the ATP level and the anti-apoptotic factor Bcl-2, while down-regulation of pro-apoptotic factor caspase-9 occurs, lowering the occurrence of apoptosis, which support the hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.