ArticleEvidence-based complementary and alternative medicine : eCAM2006
Royal jelly prevents osteoporosis in rats: beneficial effects in ovariectomy model and in bone tissue culture model.
Article in Evidence-based complementary and alternative medicine : eCAM, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 87 citations in OpenAlex.
- Applications of honeybee-derived products in bone tissue engineering.Bone reports · 2024Review
- Effects of 10-Hydroxy-2-decenoic Acid and 10-Hydroxydecanoic Acid in Royal Jelly on Bone Metabolism in Ovariectomized Rats: A Pilot Study.Journal of clinical medicine · 2023Article
- Royal Jelly as an Intelligent Anti-Aging Agent-A Focus on Cognitive Aging and Alzheimer's Disease: A Review.Antioxidants (Basel, Switzerland) · 2020Review
- The key royal jelly component 10-hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4.The Journal of biological chemistry · 2020Article
- Royal Jelly-A Traditional and Natural Remedy for Postmenopausal Symptoms and Aging-Related Pathologies.Molecules (Basel, Switzerland) · 2020Review
- Article
- Highly effective fibrin biopolymer scaffold for stem cells upgrading bone regeneration.Materials (Basel, Switzerland) · 2020Article
- Freeze-Dried Royal Jelly Proteins Enhanced the Testicular Development and Spermatogenesis in Pubescent Male Mice.Animals : an open access journal from MDPI · 2019Article
- Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans.International journal of molecular sciences · 2019Review
- Article
- Antioxidant and protective effects of Royal jelly on histopathological changes in testis of diabetic rats.International journal of reproductive biomedicine · 2016Article
- Evaluation of food products fortified with oyster shell for the prevention and treatment of osteoporosis.Journal of food science and technology · 2015Article
- Methanol Extract of Euchelus asper Prevents Bone Resorption in Ovariectomised Mice Model.Journal of osteoporosis · 2014Article
- Preventive effects of collagen Peptide from deer sinew on bone loss in ovariectomized rats.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Olive oil effectively mitigates ovariectomy-induced osteoporosis in rats.BMC complementary and alternative medicine · 2011Article
- Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans.PloS one · 2011Article
- Antiosteoporotic Activity of Dioscorea alata L. cv. Phyto through Driving Mesenchymal Stem Cells Differentiation for Bone Formation.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- AMP N(1)-oxide, a unique compound of royal jelly, induces neurite outgrowth from PC12 cells via signaling by protein kinase A independent of that by mitogen-activated protein kinase.Evidence-based complementary and alternative medicine : eCAM · 2010Article
- Estrogenic activities of Fatty acids and a sterol isolated from royal jelly.Evidence-based complementary and alternative medicine : eCAM · 2008Article
- Ki-energy (life-energy) stimulates osteoblastic cells and inhibits the formation of osteoclast-like cells in bone cell culture models.Evidence-based complementary and alternative medicine : eCAM · 2007Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Royal jelly (RJ) has been used worldwide for many years as medical products, health foods and cosmetics. Since RJ contains testosterone and has steroid hormone-type activities, we hypothesized that it may have beneficial effects on osteoporosis. We used both an ovariectomized rat model and a tissue culture model. Rats were divided into eight groups as follows: sham-operated (Sham), ovariectomized (OVX), OVX given 0.5% (w/w) raw RJ, OVX given 2.0% (w/w) RJ, OVX given 0.5% (w/w) protease-treated RJ (pRJ), OVX given 2.0% (w/w) pRJ, OVX given 17beta-estradiol and OVX given its vehicle, respectively. The Ovariectomy decreased tibial bone mineral density (BMD) by 24%. Administration of 17beta-estradiol to OVX rats recovered the tibial BMD decrease by 100%. Administration of 2.0% (w/w) RJ and 0.5-2.0% (w/w) pRJ to OVX rats recovered it by 85% or more. These results indicate that both RJ and pRJ are almost as effective as 17beta-estradiol in preventing the development of bone loss induced by ovariectomy in rats. In tissue culture models, both RJ and pRJ increased calcium contents in femoral-diaphyseal and femoral-metaphyseal tissue cultures obtained from normal male rats. However, in a mouse marrow culture model, they neither inhibited the parathyroid hormone (PTH)-induced calcium loss nor affected the formation of osteoclast-like cells induced by PTH in mouse marrow culture system. Therefore, our results suggest that both RJ and pRJ may prevent osteoporosis by enhancing intestinal calcium absorption, but not by directly antagonizing the action of PTH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.