ArticleGenetics2006
Complex genetic architecture revealed by analysis of high-density lipoprotein cholesterol in chromosome substitution strains and F2 crosses.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Quantitative trait locus mapping analysis of multiple traits when using genotype data with potential errors.PeerJ · 2021Article
- Identification of Quantitative Trait Loci That Determine Plasma Total-Cholesterol and Triglyceride Concentrations in DDD/Sgn and C57BL/6J Inbred Mice.Cholesterol · 2017Article
- Mapping and Congenic Dissection of Genetic Loci Contributing to Hyperglycemia and Dyslipidemia in Mice.PloS one · 2016Article
- Chromosomal assignment of quantitative trait loci influencing baseline circulating total cholesterol level in male laboratory mice: report of a consomic strain survey and comparison with published results.BMC research notes · 2015Article
- Effect of chromosome substitution on intrinsic exercise capacity in mice.F1000Research · 2014Article
- Identification of a novel polymorphism in X-linked sterol-4-alpha-carboxylate 3-dehydrogenase (Nsdhl) associated with reduced high-density lipoprotein cholesterol levels in I/LnJ mice.G3 (Bethesda, Md.) · 2013Article
- Recalculation of 23 mouse HDL QTL datasets improves accuracy and allows for better candidate gene analysis.Journal of lipid research · 2013Article
- Genetic control of high density lipoprotein-cholesterol in AcB/BcA recombinant congenic strains of mice.Physiological genomics · 2012Article
- Review
- Genetic basis of atherosclerosis: insights from mice and humans.Circulation research · 2012Review
- Modifier genes and non-genetic factors reshape anatomical deficits in Zfp423-deficient mice.Human molecular genetics · 2011Article
- The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol.Journal of lipid research · 2011Article
- Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross.PloS one · 2010Article
- Genetic resistance to diet-induced obesity in chromosome substitution strains of mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- An experimental assessment of in silico haplotype association mapping in laboratory mice.BMC genetics · 2009Article
- Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene.Journal of lipid research · 2009Article
- Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- Genetic analysis of the psychostimulant effects of nicotine in chromosome substitution strains and F2 crosses derived from A/J and C57BL/6J progenitors.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Differences in DBA/1J and DBA/2J reveal lipid QTL genes.Journal of lipid research · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Intercrosses between inbred lines provide a traditional approach to analysis of polygenic inheritance in model organisms. Chromosome substitution strains (CSSs) have been developed as an alternative to accelerate the pace of gene identification in quantitative trait mapping. We compared a classical intercross and three CSS intercrosses to examine the genetic architecture underlying plasma high-density lipoprotein cholesterol (HDL) levels in the C57BL/6J (B) and A/J (A) mouse strains. The B x A intercross revealed significant quantitative trait loci (QTL) for HDL on chromosomes 1, 4, 8, 15, 17, 18, and 19. A CSS survey revealed that many have significantly different HDL levels compared to the background strain B, including chromosomes with no significant QTL in the intercross and, in some cases (CSS-1, CSS-17), effects that are opposite to those observed in the B x A intercross population. Intercrosses between B and three CSSs (CSS-3, CSS-11, and CSS-8) revealed significant QTL but with some unexpected differences from the B x A intercross. Our inability to predict the results of CSS intercrosses suggests that additional complexity will be revealed by further crosses and that the CSS mapping strategy should be viewed as a complement to, rather than a replacement for, classical intercross mapping.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.