ArticleGenetics2006
Misregulation of sex-lethal and disruption of male-specific lethal complex localization in Drosophila species hybrids.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Aberrant X chromosome dosage compensation causes hybrid male inviability inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Nucleotide-level distance metrics to quantify alternative splicing implemented in TranD.Nucleic acids research · 2024Article
- Drosophila Satellite Repeats at the Intersection of Chromatin, Gene Regulation and Evolution.Progress in molecular and subcellular biology · 2021Article
- A screen for F1 hybrid male rescue reveals no major-effect hybrid lethality loci in the Drosophila melanogaster autosomal genome.G3 (Bethesda, Md.) · 2014Article
- Recurrent turnover of chromosome-specific satellites in Drosophila.Genome biology and evolution · 2014Article
- Fine mapping of dominant X-linked incompatibility alleles in Drosophila hybrids.PLoS genetics · 2014Article
- Piwi Proteins and piRNAs step onto the systems biology stage.Advances in experimental medicine and biology · 2014Article
- Male-specific lethal complex in Drosophila counteracts histone acetylation and does not mediate dosage compensation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Faster-X evolution of gene expression in Drosophila.PLoS genetics · 2012Article
- Article
- Ninety years of Drosophila melanogaster hybrids.Genetics · 2010Article
- Genetic testing of the hypothesis that hybrid male lethality results from a failure in dosage compensation.Genetics · 2010Article
- Imprinting of the Y chromosome influences dosage compensation in roX1 roX2 Drosophila melanogaster.Genetics · 2009Article
- Regulatory divergence in Drosophila melanogaster and D. simulans, a genomewide analysis of allele-specific expression.Genetics · 2009Article
- Interaction study of the male specific lethal (MSL) complex and trans-acting dosage effects in metafemales of Drosophila melanogaster.Cytogenetic and genome research · 2009Article
- Positive selection at the binding sites of the male-specific lethal complex involved in dosage compensation in Drosophila.Genetics · 2008Article
- Article
- Species-specific positive selection of the male-specific lethal complex that participates in dosage compensation in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
A major model system for the study of evolutionary divergence between closely related species has been the unisexual lethality resulting from reciprocal crosses of Drosophila melanogaster and D. simulans. Sex-lethal (Sxl), a critical gene for sex determination, is misregulated in these hybrids. In hybrid males from D. melanogaster mothers, there is an abnormal expression of Sxl and a failure of localization of the male-specific lethal (MSL) complex to the X chromosome, which causes changes in gene expression. Introduction of a Sxl mutation into this hybrid genotype will allow expression of the MSL complex but there is no sequestration to the X chromosome. Lethal hybrid rescue (Lhr), which allows hybrid males from this cross to survive, corrects the SXL and MSL defects. The reciprocal cross of D. simulans mothers by D. melanogaster males exhibits underexpression of Sxl in embryos.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.