ArticleGenetics2006
Using dominance relationship coefficients based on linkage disequilibrium and linkage with a general complex pedigree to increase mapping resolution.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Fine-mapping and identification of candidate causal genes for tail length in the Merinolandschaf breed.Communications biology · 2022Article
- A scalable, clinically severe pig model for Duchenne muscular dystrophy.Disease models & mechanisms · 2021Article
- A de novo frameshift mutation in ZEB2 causes polledness, abnormal skull shape, small body stature and subfertility in Fleckvieh cattle.Scientific reports · 2020Article
- Are scurs in heterozygous polled (Pp) cattle a complex quantitative trait?Genetics, selection, evolution : GSE · 2020Article
- A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits.American journal of human genetics · 2020Article
- Remapping of the belted phenotype in cattle on BTA3 identifies a multiplication event as the candidate causal mutation.Genetics, selection, evolution : GSE · 2018Article
- Whole-genome analysis of introgressive hybridization and characterization of the bovine legacy of Mongolian yaks.Nature genetics · 2017Article
- Confirmation of a non-synonymous SNP in PNPLA8 as a candidate causal mutation for Weaver syndrome in Brown Swiss cattle.Genetics, selection, evolution : GSE · 2016Article
- Genome-wide QTL mapping of nine body composition and bone mineral density traits in pigs.Genetics, selection, evolution : GSE · 2014Article
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2 authors.
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Abstract
Dominance (intralocus allelic interactions) plays often an important role in quantitative trait variation. However, few studies about dominance in QTL mapping have been reported in outbred animal or human populations. This is because common dominance effects can be predicted mainly for many full sibs, which do not often occur in outbred or natural populations with a general pedigree. Moreover, incomplete genotypes for such a pedigree make it infeasible to estimate dominance relationship coefficients between individuals. In this study, identity-by-descent (IBD) coefficients are estimated on the basis of population-wide linkage disequilibrium (LD), which makes it possible to track dominance relationships between unrelated founders. Therefore, it is possible to use dominance effects in QTL mapping without full sibs. Incomplete genotypes with a complex pedigree and many markers can be efficiently dealt with by a Markov chain Monte Carlo method for estimating IBD and dominance relationship matrices (D(RM)). It is shown by simulation that the use of D(RM) increases the likelihood ratio at the true QTL position and the mapping accuracy and power with complete dominance, overdominance, and recessive inheritance modes when using 200 genotyped and phenotyped individuals.
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