ArticleGenetics2006
Pronounced differences of recombination activity at the sex determination locus of the honeybee, a locus under strong balancing selection.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- LncRNA geneScience advances · 2024Article
- Variability and Number of CirculatingGenes · 2024Article
- Application of Next Generation Semiconductor-Based Sequencing for the Identification ofInsects · 2021Article
- An Alternative, High Throughput Method to IdentifyInsects · 2020Article
- Substantial Heritable Variation in Recombination Rate on Multiple Scales in Honeybees and Bumblebees.Genetics · 2019Article
- High-resolution linkage map for two honeybee chromosomes: the hotspot quest.Molecular genetics and genomics : MGG · 2014Article
- Nucleotide variability at its limit? Insights into the number and evolutionary dynamics of the sex-determining specificities of the honey bee Apis mellifera.Molecular biology and evolution · 2014Article
- Independent evolutionary origin of fem paralogous genes and complementary sex determination in hymenopteran insects.PloS one · 2014Article
- Targeted sequence capture provides insight into genome structure and genetics of male sterility in a gynodioecious diploid strawberry, Fragaria vesca ssp. bracteata (Rosaceae).G3 (Bethesda, Md.) · 2013Article
- Review
- Polymorphism analysis of csd gene in six Apis mellifera subspecies.Molecular biology reports · 2012Article
- The sex determination gene shows no founder effect in the giant honey bee, Apis dorsata.PloS one · 2012Article
- Contrasted patterns of molecular evolution in dominant and recessive self-incompatibility haplotypes in Arabidopsis.PLoS genetics · 2012Article
- Function and evolution of sex determination mechanisms, genes and pathways in insects.BioEssays : news and reviews in molecular, cellular and developmental biology · 2011Review
- Origin of a function by tandem gene duplication limits the evolutionary capability of its sister copy.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Sex determination in honeybees: two separate mechanisms induce and maintain the female pathway.PLoS biology · 2009Article
- Experimental support for multiple-locus complementary sex determination in the parasitoid Cotesia vestalis.Genetics · 2008Article
- Thelytokous parthenogenesis in unmated queen honeybees (Apis mellifera capensis): central fusion and high recombination rates.Genetics · 2008Article
- Evidence for the evolutionary nascence of a novel sex determination pathway in honeybees.Nature · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombination decreases the association of linked nucleotide sites and can influence levels of polymorphism in natural populations. When coupled with selection, recombination may relax potential conflict among linked genes, a concept that has played a central role in research on the evolution of recombination. The sex determination locus (SDL) of the honeybee is an informative example for exploring the combined forces of recombination, selection, and linkage on sequence evolution. Balancing selection at SDL is very strong and homozygous individuals at SDL are eliminated by worker bees. The recombination rate is increased up to four times that of the genomewide average in the region surrounding SDL. Analysis of nucleotide diversity (pi) reveals a sevenfold increase of polymorphism within the sex determination gene complementary sex determiner (csd) that rapidly declines within 45 kb to levels of genomewide estimates. Although no recombination was observed within SDL, which contains csd, analyses of heterogeneity, shared polymorphic sites, and linkage disequilibrium (LD) show that recombination has contributed to the evolution of the 5' part of some csd sequences. Gene conversion, however, has not obviously contributed to the evolution of csd sequences. The local control of recombination appears to be related to SDL function and mode of selection. The homogenizing force of recombination is reduced within SDL, which preserves allelic differences and specificity, while the increase of recombination activity around SDL relaxes conflict between SDL and linked genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.