ArticlePlant physiology2006
Molecular identification of an Arabidopsis S-adenosylmethionine transporter. Analysis of organ distribution, bacterial expression, reconstitution into liposomes, and functional characterization.
Article in Plant physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 99 citations in OpenAlex.
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- Roles of S-Adenosylmethionine and Its Derivatives in Salt Tolerance of Cotton.International journal of molecular sciences · 2023Review
- Combining GWAS and TWAS to identify candidate causal genes for tocochromanol levels in maize grain.Genetics · 2022Article
- Golgi-localized putative S-adenosyl methionine transporters required for plant cell wall polysaccharide methylation.Nature plants · 2022Article
- Aberrant Expression of Mitochondrial SAM Transporter SLC25A26 Impairs Oocyte Maturation and Early Development in Mice.Oxidative medicine and cellular longevity · 2022Article
- Metabolism and Regulatory Functions ofFrontiers in plant science · 2021Review
- Characterization of In Vivo Function(s) of Members of the Plant Mitochondrial Carrier Family.Biomolecules · 2020Review
- Metabolic Roles of Plant Mitochondrial Carriers.Biomolecules · 2020Review
- Diseases Caused by Mutations in Mitochondrial Carrier GenesBiomolecules · 2020Review
- Mitochondrial Carriers for Aspartate, Glutamate and Other Amino Acids: A Review.International journal of molecular sciences · 2019Review
- TaBT1, affecting starch synthesis and thousand kernel weight, underwent strong selection during wheat improvement.Journal of experimental botany · 2019Article
- MitochondrialFrontiers in plant science · 2019Article
- Xylan in the Middle: Understanding Xylan Biosynthesis and Its Metabolic Dependencies Toward Improving Wood Fiber for Industrial Processing.Frontiers in plant science · 2019Review
- Uncoupling proteins 1 and 2 (UCP1 and UCP2) fromThe Journal of biological chemistry · 2018Article
- Mitochondrial ATP-Mg/phosphate carriers transport divalent inorganic cations in complex with ATP.Journal of bioenergetics and biomembranes · 2017Article
- OsBT1 encodes an ADP-glucose transporter involved in starch synthesis and compound granule formation in rice endosperm.Scientific reports · 2017Article
- Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26.American journal of human genetics · 2015Article
- The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters.The Journal of biological chemistry · 2014Article
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8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite much study of the role of S-adenosylmethionine (SAM) in the methylation of DNA, RNA, and proteins, and as a cofactor for a wide range of biosynthetic processes, little is known concerning the intracellular transport of this essential metabolite. Screening of the Arabidopsis (Arabidopsis thaliana) genome yielded two potential homologs of yeast (Saccharomyces cerevisiae) and human SAM transporters, designated as SAMC1 and SAMC2, both of which belong to the mitochondrial carrier protein family. The SAMC1 gene is broadly expressed at the organ level, although only in specialized tissues of roots with high rates of cell division, and appears to be up-regulated in response to wounding stress, whereas the SAMC2 gene is very poorly expressed in all organs/tissues analyzed. Direct transport assays with the recombinant and reconstituted SAMC1 were utilized to demonstrate that this protein displays a very narrow substrate specificity confined to SAM and its closest analogs. Further experiments revealed that SAMC1 was able to function in uniport and exchange reactions and characterized the transporter as highly active, but sensitive to physiologically relevant concentrations of S-adenosylhomocysteine, S-adenosylcysteine, and adenosylornithine. Green fluorescent protein-based cell biological analysis demonstrated targeting of SAMC1 to mitochondria. Previous proteomic analyses identified this protein also in the chloroplast inner envelope. In keeping with these results, bioinformatics predicted dual localization for SAMC1. These findings suggest that the provision of cytosolically synthesized SAM to mitochondria and possibly also to plastids is mediated by SAMC1 according to the relative demands for this metabolite in the organelles.
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