ArticleBiosensors & bioelectronics2007
DNA single-base mismatch study with an electrochemical enzymatic genosensor.
Article in Biosensors & bioelectronics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Selective electrochemical discrimination of 3' isomiRs differing by two nucleotides.The Analyst · 2026Article
- Sensitive detection of dengue serotype-4 on lignin-derived graphene nanofibre and manganese oxide composite by DNA-sensing.Scientific reports · 2025Article
- Article
- Cyclic GMP-AMP synthase recognizes the physical features of DNA.Acta pharmacologica Sinica · 2025Review
- The potential of electrochemistry for the detection of coronavirus-induced infections.Trends in analytical chemistry : TRAC · 2020Review
- SPR Detection and Discrimination of the Oligonucleotides Related to the Normal and the Hybrid bcr-abl Genes by Two Stringency Control Strategies.Nanoscale research letters · 2016Article
- Ni2+-enhanced charge transport via π-π stacking corridor in metallic DNA.Biophysical journal · 2011Article
- Microfluidics-based lab-on-chip systems in DNA-based biosensing: an overview.Sensors (Basel, Switzerland) · 2011Review
- State-of-the-art of (bio)chemical sensor developments in analytical Spanish groups.Sensors (Basel, Switzerland) · 2010Review
- Overview of electrochemical DNA biosensors: new approaches to detect the expression of life.Sensors (Basel, Switzerland) · 2009Article
- Electroactive intercalators for DNA analysis on microchip electrophoresis.Electrophoresis · 2007Article
- Antimicrobial resistance induced by genetic changes.Journal of medicine and lifeReview
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A thorough selectivity study of DNA hybridization employing an electrochemical enzymatic genosensor is discussed here. After immobilizing on a gold film a 30-mer 3'-thiolated DNA strand, hybridization with a biotinylated complementary one takes place. Then, alkaline phosphatase is incorporated to the duplex through the interaction streptavidin-biotin. Enzymatic generation of indigo blue from 3-indoxyl phosphate and subsequent electrochemical detection was made. The influence of hybridization conditions was studied in order to better discern between fully complementary and mismatched strands. Detection of 3, 2 and 1 mismatch was possible. The type and location of the single-base mismatch, as well as the influence of the length of the strands was studied too. Mutations that suppose displacement of the reading frame were also considered. The effect of the concentration on the selectivity was tested, resulting a highly selective genosensor with an adequate sensitivity and stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.