ArticleProceedings of the National Academy of Sciences of the United States of America1990
Interleukin 1 receptor blockade attenuates the host inflammatory response.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 214 citations in OpenAlex.
- Article
- Myeloperoxidase instigates proinflammatory responses in a cecal ligation and puncture rat model of sepsis.American journal of physiology. Heart and circulatory physiology · 2020Article
- The role of interleukin-6 in glucose homeostasis and lipid metabolism.Seminars in immunopathology · 2019Review
- Is there value in plasma cytokine measurements in patients with severe trauma and sepsis?Methods (San Diego, Calif.) · 2013Review
- Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response.Journal of thrombosis and haemostasis : JTH · 2013Article
- Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.Brain, behavior, and immunity · 2007Article
- The immune properties of mesenchymal stem cells.International journal of biomedical science : IJBS · 2007Article
- The use of anakinra in juvenile arthritis.Current rheumatology reports · 2005Review
- Interleukin-1beta induced vascular permeability is dependent on induction of endothelial tissue factor (TF) activity.Journal of translational medicine · 2005Article
- Role of tumour necrosis factor-alpha and other cytokines in ischemia-reperfusion-induced injury in the heart.Experimental and clinical cardiology · 2005Article
- Immunosuppressive and anti-inflammatory effects of nicotine administered by patch in an animal model.Clinical and diagnostic laboratory immunology · 2004Article
- A polymorphism of the interleukin-1 beta gene influences survival in pancreatic cancer.British journal of cancer · 2000Article
- Liposome-mediated, nonviral gene transfer induces a systemic inflammatory response which can exacerbate pre-existing inflammation.Gene therapy · 2000Article
- [Pathophysiology of catabolism in undernurished elderly patients].Zeitschrift fur Gerontologie und Geriatrie · 1999Review
- Article
- Peritoneal lavage reduces lipopolysaccharide-induced elevation of serum TNF-alpha and IL-6 mortality in mice.Inflammation · 1997Article
- Infra-red laser irradiation enhances interleukin-1 receptor antagonist, increases 3H-thymidine incorporation and the release of [3H]arachidonic acid in human monocytes.Molecular and cellular biochemistry · 1997Article
- Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.The Journal of clinical investigation · 1997Article
- Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone.The Journal of experimental medicine · 1996Article
- Inflammation-induced recombinant protein expression in vivo using promoters from acute-phase protein genes.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Cytokines, including interleukin 1 (IL-1), tumor necrosis factor alpha, and interleukin 6, are often produced in response to tissue injury and contribute to several host responses such as weight loss, anorexia, and acute-phase protein synthesis. However, the role of IL-1 in specific tissue responses is unclear. To test our hypothesis that specific in vivo blockade of IL-1's action might inhibit the catabolic host changes associated with inflammation, mice were passively immunized with a monoclonal antibody directed against the murine IL-1 receptor prior to initiation of a turpentine-induced sterile abscess. This antibody prevents IL-1-mediated proliferation of murine thymocytes in vitro by inhibiting IL-1 alpha and IL-1 beta by way of competition for a common receptor. Weight loss following turpentine challenge was prevented by daily injections of anti-IL-1 receptor monoclonal IgG. Body composition analysis confirmed that lean tissue and fat were preserved by passive immunization. Furthermore, pretreatment with an anti-IL-1 receptor monoclonal antibody significantly attenuated the plasma amyloid P and interleukin 6 responses but did not affect the decline in plasma albumin or the increase in circulating corticosterone. Passive immunization of similar mice with polyclonal antisera against another cytokine, tumor necrosis factor alpha, failed to prevent either the weight loss or hepatic acute-phase protein changes observed in this inflammatory model. These findings suggest that IL-1 orchestrates weight loss and body compositional changes during inflammation and contributes to the induction of interleukin 6 and acute-phase protein synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.