ArticleMechanisms of development2006
Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart.
Article in Mechanisms of development, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Backbone and side-chain resonance assignments of (CaBiomolecular NMR assignments · 2017Article
- An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood.Developmental biology · 2015Article
- Examining the cardiac NK-2 genes in early heart development.Pediatric cardiology · 2010Review
- Echocardiographic assessment of cardiac morphology and function in Xenopus.Comparative medicine · 2010Article
- Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number.Developmental biology · 2008Article
- Lessons from the lily pad: Using Xenopus to understand heart disease.Drug discovery today. Disease models · 2008Article
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Authors and funding
3 authors.
Funding
Abstract
Normal vertebrate heart development depends upon the expression of homeodomain containing proteins related to the Drosophila gene, tinman. In Xenopus laevis, three such genes have been identified in regions that will eventually give rise to the heart, XNkx2-3, XNkx2-5 and XNkx2-10. Although the expression domains of all three overlap in early development, distinctive differences have been noted. By the time the heart tube forms, there is little XNkx2-10 mRNA detected by in situ analysis in the embryonic heart while both XNkx2-3 and XNkx2-5 are clearly present. In addition, unlike XNkx2-3 and XNkx2-5, injection of XNkx2-10 mRNA does not increase the size of the embryonic heart. We have reexamined the expression and potential role of XNkx2-10 in development via oligonucleotide-mediated reduction of XNkx2-10 protein expression. We find that a decrease in XNkx2-10 leads to a broad spectrum of developmental abnormalities including a reduction in heart size. We conclude that XNkx2-10, like XNkx2-3 and XNkx2-5, is necessary for normal Xenopus heart development.
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