ArticleDevelopmental biology2006
Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte.
Article in Developmental biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Oocyte Maturation in Starfish.Cells · 2020Review
- Luteinizing hormone signaling phosphorylates and activates the cyclic GMP phosphodiesterase PDE5 in mouse ovarian follicles, contributing an additional component to the hormonally induced decrease in cyclic GMP that reinitiates meiosis.Developmental biology · 2018Article
- Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle.Annual review of physiology · 2017Review
- Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis.Biology of reproduction · 2016Article
- Physiologic Course of Female Reproductive Function: A Molecular Look into the Prologue of Life.Journal of pregnancy · 2015Review
- Identification of phosphodiesterase 9A as a cyclic guanosine monophosphate-specific phosphodiesterase in germinal vesicle oocytes: a proposed role in the resumption of meiosis.Fertility and sterility · 2012Article
- Novel signaling mechanisms in the ovary during oocyte maturation and ovulation.Molecular and cellular endocrinology · 2012Review
- Hormonal control of mammalian oocyte meiosis at diplotene stage.Cellular and molecular life sciences : CMLS · 2012Review
- Expression of insulin-like 3 (INSL3) and differential splicing of its receptor in the ovary of rhesus macaques.Reproductive biology and endocrinology : RB&E · 2010Article
- Regulation of the G2/M transition in rodent oocytes.Molecular reproduction and development · 2010Review
- Article
- Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte.Development (Cambridge, England) · 2009Article
- Functions of Fyn kinase in the completion of meiosis in mouse oocytes.Developmental biology · 2009Article
- Microinjection of follicle-enclosed mouse oocytes.Methods in molecular biology (Clifton, N.J.) · 2009Article
- A G(s)-linked receptor maintains meiotic arrest in mouse oocytes, but luteinizing hormone does not cause meiotic resumption by terminating receptor-G(s) signaling.Developmental biology · 2007Article
- G beta gamma signaling reduces intracellular cAMP to promote meiotic progression in mouse oocytes.Steroids · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The signaling pathway by which luteinizing hormone (LH) acts on the somatic cells of vertebrate ovarian follicles to stimulate meiotic resumption in the oocyte requires a decrease in cAMP in the oocyte, but how cAMP is decreased is unknown. Activation of Gi family G proteins can lower cAMP by inhibiting adenylate cyclase or stimulating a cyclic nucleotide phosphodiesterase, but we show here that inhibition of this class of G proteins by injection of pertussis toxin into follicle-enclosed mouse oocytes does not prevent meiotic resumption in response to LH. Likewise, elevation of Ca2+ can lower cAMP through its action on Ca2+-sensitive adenylate cyclases or phosphodiesterases, but inhibition of a Ca2+ rise by injection of EGTA into follicle-enclosed mouse oocytes does not inhibit the LH response. Thus, neither of these well-known mechanisms of cAMP regulation can account for LH signaling to the oocyte in the mouse ovary.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.