Trial reportLipids in health and disease2006
The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome.
Trial report in Lipids in health and disease, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 95 citations in OpenAlex.
- The Use of a Stem and Leaf Aqueous Extract of Cissus quadrangularis (CQR-300) to Reduce Body Fat and Other Components of Metabolic Syndrome in Overweight Participants.Journal of alternative and complementary medicine (New York, N.Y.) · 2019Trial
- Efficacy and tolerability of a novel herbal formulation for weight management in obese subjects: a randomized double blind placebo controlled clinical study.Lipids in health and disease · 2012Trial
- The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study.Lipids in health and disease · 2008Trial
- The effects of ProAlgaZyme novel algae infusion on metabolic syndrome and markers of cardiovascular health.Lipids in health and disease · 2007Trial
- Morphological, molecular, and pharmacological review of veldt grape (Frontiers in plant science · 2025Review
- Evaluation of the anti-osteoarthritic effects and mechanisms ofFood & nutrition research · 2025Article
- Review
- Extracts from the Leaves ofPlants (Basel, Switzerland) · 2021Article
- Depletion of β-sitosterol and enrichment of quercetin and rutin in Cissus quadrangularis Linn fraction enhanced osteogenic but reduced osteoclastogenic marker expression.BMC complementary medicine and therapies · 2020Article
- Bioactivity-Guided Isolation and Identification of Anti-adipogenic Constituents from the n-Butanol Fraction of Cissus quadrangularis.Critical reviews in eukaryotic gene expression · 2020Article
- A short review on pharmacological activity of Cissus quadrangularis.Bioinformation · 2020Article
- Plant Extracts and Reactive Oxygen Species as Two Counteracting Agents with Anti- and Pro-Obesity Properties.International journal of molecular sciences · 2019Review
- Effect of Myristica fragrans extract on total body composition in cafeteria diet induced obese rats.Bioinformation · 2019Article
- Obesity-alleviating potential of asiatic acid and its effects on ACC1, UCP2, and CPT1 mRNA expression in high fat diet-induced obese Sprague-Dawley rats.Molecular and cellular biochemistry · 2018Article
- Antiobesity Activities of Methanolic Extracts ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Cissus quadrangularis extract attenuates hyperglycaemia-mediated oxidative stress in streptozotocin-induced diabetic rats.Redox report : communications in free radical research · 2014Article
- Osteogenic potential of cissus qudrangularis assessed with osteopontin expression.National journal of maxillofacial surgery · 2013Article
- Ultra high-performance liquid chromatography with high-resolution mass spectrometry analysis of African mango (Irvingia gabonensis) seeds, extract, and related dietary supplements.Journal of agricultural and food chemistry · 2012Article
- Natural products: a safest approach for obesity.Chinese journal of integrative medicine · 2012Review
- Science of weight loss supplements: compromised by conflicts of interest?World journal of gastroenterology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimOnce considered a problem of developed countries, obesity and obesity-related complications (such as metabolic syndrome) are rapidly spreading around the globe. The purpose of the present study was to investigate the use of a Cissus quadrangularis formulation in the management of metabolic syndrome, particularly weight loss and central obesity.
methodsThe study was a randomized, double-blind, placebo-controlled design involving 123 overweight and obese persons (47.2% male; 52.8% female; ages 19-50). The 92 obese (BMI >30) participants were randomized into three groups; placebo, formulation/no diet, and formulation/diet (2100-2200 calories/day). The 31 overweight participants (BMI = 25-29) formed a fourth (no diet) treatment group. All participants received two daily doses of the formulation or placebo and remained on a normal or calorie-controlled diet for 8 weeks.
resultsAt the end of the trial period, statistically significant net reductions in weight and central obesity, as well as in fasting blood glucose, total cholesterol, LDL-cholesterol, triglycerides, and C-reactive protein were observed in participants who received the formulation, regardless of diet.
conclusionCissus quadrangularis formulation appears to be useful in the management of weight loss and metabolic syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.