ArticleThe EMBO journal2006
Dazl can bind to dynein motor complex and may play a role in transport of specific mRNAs.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Association between DAZL polymorphisms and susceptibility to male infertility: systematic review with meta-analysis and trial sequential analysis.Scientific reports · 2014Pooled it
- Anatomy and Function of Deleted in Azoospermia Like (DAZL) Gene in Human and Mouse.Development & reproduction · 2025Article
- AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans.Cell death & disease · 2024Article
- High cholesterol diet-induced testicular dysfunction in rats.Hormones (Athens, Greece) · 2023Article
- DLC-1 facilitates germ granule assembly inMolecular biology of the cell · 2022Article
- Transcriptional regulation of P63 on the apoptosis of male germ cells and three stages of spermatogenesis in mice.Cell death & disease · 2018Article
- TheJournal of cell science · 2017Article
- BOULE, a Deleted in Azoospermia Homolog, Is Recruited to Stress Granules in the Mouse Male Germ Cells.PloS one · 2016Article
- Dynamic intracellular localization of Dazl protein during Xenopus germline development.Histochemistry and cell biology · 2015Article
- Maternal dazap2 Regulates Germ Granules by Counteracting Dynein in Zebrafish Primordial Germ Cells.Cell reports · 2015Article
- DAZ Family Proteins, Key Players for Germ Cell Development.International journal of biological sciences · 2015Review
- Ribonomic analysis of human DZIP1 reveals its involvement in ribonucleoprotein complexes and stress granules.BMC molecular biology · 2014Article
- NMR Characterization of Self-Association Domains Promoted by Interactions with LC8 Hub Protein.Computational and structural biotechnology journal · 2014Review
- Heat stress response of male germ cells.Cellular and molecular life sciences : CMLS · 2013Review
- A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice.PloS one · 2013Article
- Scaffold remodeling in space and time controls synaptic transmission.Bioarchitecture · 2012Article
- Identification and characterization of RBM44 as a novel intercellular bridge protein.PloS one · 2011Article
- Molecular motor proteins and amyotrophic lateral sclerosis.International journal of molecular sciences · 2011Review
- The roles of the DAZ family in spermatogenesis: More than just translation?Spermatogenesis · 2011Article
- Testis transcriptome analysis in male infertility: new insight on the pathogenesis of oligo-azoospermia in cases with and without AZFc microdeletion.BMC genomics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Male germ cell development includes mitotic and meiotic cell divisions that are followed by dramatic morphological changes resulting in the production of spermatozoa. Genetic evidence has indicated that the DAZ family genes are critical for successful male germ cell development in diverse animals as well as humans. In the present study, we investigated the cellular functions of Dazl in the mouse male germ cells. We identified a specific interaction of Dazl with the dynein light chain, a component of the dynein-dynactin motor complex. The subcellular distribution of Dazl was microtubule-dependent and a selected number of Dazl-bound mRNAs could accumulate in the perinuclear area. Based on these results, we propose that Dazl may play a role in transport of specific mRNAs via dynein motor complex. The Dazl-bound mRNAs may be stored at specific sites and would be available for future developmental processes. Our study revealed the presence of an active mRNA transport system in mouse male germ cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.