ArticleThe EMBO journal2006
3'-end formation signals modulate the association of genes with the nuclear periphery as well as mRNP dot formation.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed.
- Intergenic accumulation of RNA polymerase II maintains the potential for swift transcriptional restart upon release from quiescence.Genome research · 2025Article
- A R-loop sensing pathway mediates the relocation of transcribed genes to nuclear pore complexes.Nature communications · 2023Article
- Article
- Brr6 plays a role in gene recruitment and transcriptional regulation at the nuclear envelope.Molecular biology of the cell · 2018Article
- Quantitative imaging of chromatin decompaction in living cells.Molecular biology of the cell · 2018Article
- Stem-loop RNA labeling can affect nuclear and cytoplasmic mRNA processing.RNA (New York, N.Y.) · 2017Article
- Co-transcriptional degradation by the 5'-3' exonuclease Rat1p mediates quality control of HXK1 mRNP biogenesis in S. cerevisiae.RNA biology · 2016Article
- Global reorganization of budding yeast chromosome conformation in different physiological conditions.The Journal of cell biology · 2016Article
- Scarless Gene Tagging with One-Step Transformation and Two-Step Selection in Saccharomyces cerevisiae and Schizosaccharomyces pombe.PloS one · 2016Article
- From hypothesis to mechanism: uncovering nuclear pore complex links to gene expression.Molecular and cellular biology · 2014Review
- Manipulating nuclear architecture.Current opinion in genetics & development · 2014Review
- Nuclear pore interactions with the genome.Current opinion in genetics & development · 2014Review
- The Hog1 stress-activated protein kinase targets nucleoporins to control mRNA export upon stress.The Journal of biological chemistry · 2013Article
- Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression.RNA (New York, N.Y.) · 2013Article
- Structure and function in the budding yeast nucleus.Genetics · 2012Review
- ePAT: a simple method to tag adenylated RNA to measure poly(A)-tail length and other 3' RACE applications.RNA (New York, N.Y.) · 2012Article
- A negative feedback loop at the nuclear periphery regulates GAL gene expression.Molecular biology of the cell · 2012Article
- Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex.Nature structural & molecular biology · 2012Article
- A nucleoporin, Nup60p, affects the nuclear and cytoplasmic localization of ASH1 mRNA in S. cerevisiae.RNA (New York, N.Y.) · 2011Article
- A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination.Nucleic acids research · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Multiple studies indicate that mRNA processing defects cause mRNAs to accumulate in discrete nuclear foci or dots, in mammalian cells as well as yeast. To investigate this phenomenon, we have studied a series of GAL reporter constructs integrated into the yeast genome adjacent to an array of TetR-GFP-bound TetO sites. mRNA within dots is predominantly post-transcriptional, and dots are adjacent to but distinct from their transcription site. These reporter genes also localize to the nuclear periphery upon gene induction, like their endogenous GAL counterparts. Surprisingly, this peripheral localization persists long after transcriptional shutoff, and there is a comparable persistence of the RNA in the dots. Moreover, dot disappearance and gene delocalization from the nuclear periphery occur with similar kinetics after transcriptional shutoff. Both kinetics depend in turn on reporter gene 3'-end formation signals. Our experiments indicate that gene association with the nuclear periphery does not require ongoing transcription and suggest that the mRNPs within dots may make a major contribution to the gene-nuclear periphery tether.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.