ArticleThe Journal of physiology2006
Complex interplay between glutamate receptors and intracellular Ca2+ stores during ischaemia in rat spinal cord white matter.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Potential physiological and pathological roles for axonal ryanodine receptors.Neural regeneration research · 2023Review
- Direct Ryanodine Receptor-2 Knockout in Primary Afferent Fibers Modestly Affects Neurological Recovery after Contusive Spinal Cord Injury.Neurotrauma reports · 2022Article
- Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system.Nature reviews. Neuroscience · 2018Review
- Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology.Neurochemical research · 2017Review
- A Novel Approach for Studying the Physiology and Pathophysiology of Myelinated and Non-Myelinated Axons in the CNS White Matter.PloS one · 2016Article
- The Influence of Glutamate on Axonal Compound Action Potential In Vitro.Journal of brachial plexus and peripheral nerve injury · 2016Article
- Direct Current-Induced Calcium Trafficking in Different Neuronal Preparations.Neural plasticity · 2016Article
- Myelin Proteolipid Protein Complexes with αv Integrin and AMPA Receptors In Vivo and Regulates AMPA-Dependent Oligodendrocyte Progenitor Cell Migration through the Modulation of Cell-Surface GluR2 Expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Combination of mild hypothermia with neuroprotectants has greater neuroprotective effects during oxygen-glucose deprivation and reoxygenation-mediated neuronal injury.Scientific reports · 2014Article
- Changes in gap junction expression and function following ischemic injury of spinal cord white matter.Journal of neurophysiology · 2014Article
- Calcium release from intra-axonal endoplasmic reticulum leads to axon degeneration through mitochondrial dysfunction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Neurodegeneration in multiple sclerosis involves multiple pathogenic mechanisms.Degenerative neurological and neuromuscular disease · 2014Review
- Role of calpains in the injury-induced dysfunction and degeneration of the mammalian axon.Neurobiology of disease · 2013Review
- Neuroprotection in multiple sclerosis: a therapeutic approach.CNS drugs · 2013Review
- Ectopic vesicular glutamate release at the optic nerve head and axon loss in mouse experimental glaucoma.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Therapeutic potential of kainate receptors.CNS neuroscience & therapeutics · 2011Review
- Glutamate and ATP signalling in white matter pathology.Journal of anatomy · 2011Review
- Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation.Trends in molecular medicine · 2010Review
- Ionic storm in hypoxic/ischemic stress: can opioid receptors subside it?Progress in neurobiology · 2010Review
- Effects of the noradrenergic system in rat white matter exposed to oxygen-glucose deprivation in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Electrophysiological recordings of propagated compound action potentials (CAPs) and axonal Ca(2+) measurements using confocal microscopy were used to study the interplay between AMPA receptors and intracellullar Ca(2+) stores in rat spinal dorsal columns subjected to in vitro combined oxygen and glucose deprivation (OGD). Removal of Ca(2+) or Na(+) from the perfusate was protective after 30 but not 60 min of OGD. TTX was ineffective with either exposure, consistent with its modest effect on ischaemic depolarization. In contrast, AMPA antagonists were very protective, even after 60 min of OGD where 0Ca(2+) + EGTA perfusate was ineffective. Similarly, blocking ryanodine receptor-mediated Ca(2+) mobilization from internal stores (0Ca(2+) + nimodipine or 0Ca(2+) + ryanodine), or inositol 1,4,5-trisphosphate (IP(3))-dependent Ca(2+) release (block of group 1 metabotropic glutamate receptors with 1-aminoindan-1,5-dicarboxylic acid, inhibition of phospholipase C with U73122 or IP(3) receptor block with 2APB; each in 0Ca(2+)) were each very protective, with the combination resulting in virtually complete functional recovery after 1 h OGD (97 +/- 32% CAP recovery versus 4 +/- 6% in artificial cerebrospinal fluid). AMPA induced a rise in Ca(2+) concentration in normoxic axons, which was greatly reduced by blocking ryanodine receptors. Our data therefore suggest a novel and surprisingly complex interplay between AMPA receptors and Ca(2+) mobilization from intracellular Ca(2+) stores. We propose that AMPA receptors may not only allow Ca(2+) influx from the extracellular space, but may also significantly influence Ca(2+) release from intra-axonal Ca(2+) stores. In dorsal column axons, AMPA receptor-dependent mechanisms appear to exert a greater influence than voltage-gated Na(+) channels on functional outcome following OGD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.