ArticleThe Journal of physiology2006
The self-regulating nature of spontaneous synchronized activity in developing mouse cortical neurones.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Reelin Regulates Developmental Desynchronization Transition of Neocortical Network Activity.Biomolecules · 2024Article
- Article
- Large-scale waves of activity in the neonatal mouse brain in vivo occur almost exclusively during sleep cycles.Developmental neurobiology · 2022Article
- Step by step: cells with multiple functions in cortical circuit assembly.Nature reviews. Neuroscience · 2022Review
- Spontaneous synchronous network activity in the neonatal development of mPFC in mice.Developmental neurobiology · 2021Article
- Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice.Translational psychiatry · 2019Article
- GABA and Gap Junctions in the Development of Synchronized Activity in Human Pluripotent Stem Cell-Derived Neural Networks.Frontiers in cellular neuroscience · 2018Article
- Neuronal activity controls the development of interneurons in the somatosensory cortex.Frontiers in biology · 2016Article
- Automated quantification of neuronal networks and single-cell calcium dynamics using calcium imaging.Journal of neuroscience methods · 2015Article
- Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.Frontiers in cellular neuroscience · 2015Article
- Relationship between individual neuron and network spontaneous activity in developing mouse cortex.Journal of neurophysiology · 2014Article
- Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Decision making during interneuron migration in the developing cerebral cortex.Trends in cell biology · 2014Review
- Genetic elimination of GABAergic neurotransmission reveals two distinct pacemakers for spontaneous waves of activity in the developing mouse cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- An age-dependent change in the set point of synaptic homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- In vitro Differentiation of Functional Human Skeletal Myotubes in a Defined System.Biomaterials science · 2014Article
- Emergence of adaptive computation by single neurons in the developing cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- A microfluidic microelectrode array for simultaneous electrophysiology, chemical stimulation, and imaging of brain slices.Lab on a chip · 2013Article
- Layer III neurons control synchronized waves in the immature cerebral cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Waves of spontaneous electrical activity that are highly synchronized across large populations of neurones occur throughout the developing mammalian central nervous system. The stages at which this activity occurs are tightly regulated to allow activity-dependent developmental programmes to be initiated correctly. What determines the onset and cessation of spontaneous synchronous activity (SSA) in a particular region of the nervous system, however, remains unclear. We have tested the hypothesis that activity itself triggers developmental changes in intrinsic and circuit properties that determine the stages at which SSA occurs. To do this we exposed cultured slices of mouse neocortex to tetrodotoxin (TTX) to block SSA, which normally occurs between embryonic day 17 (E17) and postnatal day 3 (P3). In control cultured slices, SSA rarely occurs after P3. In TTX-treated slices, however, SSA was generated from P3 (the day of TTX removal) until at least P10. This indicates that in the absence of spontaneous activity, the mechanisms that normally determine the timing of SSA are not initiated, and that a compensatory response occurs that shifts the time of SSA occurrence to later developmental stages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.