ArticleProceedings of the National Academy of Sciences of the United States of America2006
Structure of an RNA switch that enforces stringent retroviral genomic RNA dimerization.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 38 citations in OpenAlex.
- Structural Insights into RNA Dimerization: Motifs, Interfaces and Functions.Molecules (Basel, Switzerland) · 2020Review
- Retroviral RNA Dimerization: From Structure to Functions.Frontiers in microbiology · 2018Review
- Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark.Nucleic acids research · 2015Article
- An immature retroviral RNA genome resembles a kinetically trapped intermediate state.Journal of virology · 2014Article
- The 0.3-kb fragment containing the R-U5-5'leader sequence of Friend murine leukemia virus influences the level of protein expression from spliced mRNA.Virology journal · 2013Article
- Structural effects of linkage disequilibrium on the transcriptome.RNA (New York, N.Y.) · 2012Article
- Femtomole SHAPE reveals regulatory structures in the authentic XMRV RNA genome.Journal of the American Chemical Society · 2011Article
- Structural determinants and mechanism of HIV-1 genome packaging.Journal of molecular biology · 2011Review
- A conditional random fields method for RNA sequence-structure relationship modeling and conformation sampling.Bioinformatics (Oxford, England) · 2011Article
- Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography.Journal of molecular biology · 2010Article
- Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- SHAPE-directed RNA secondary structure prediction.Methods (San Diego, Calif.) · 2010Review
- Murine leukemia virus RNA dimerization is coupled to transcription and splicing processes.Retrovirology · 2010Article
- On the significance of an RNA tertiary structure prediction.RNA (New York, N.Y.) · 2010Article
- Robust and generic RNA modeling using inferred constraints: a structure for the hepatitis C virus IRES pseudoknot domain.Biochemistry · 2010Review
- Advances in RNA structure analysis by chemical probing.Current opinion in structural biology · 2010Review
- A unique, thermostable dimer linkage structure of RD114 retroviral RNA.RNA (New York, N.Y.) · 2010Article
- An RNA structural switch regulates diploid genome packaging by Moloney murine leukemia virus.Journal of molecular biology · 2010Article
- Secondary structure of the mature ex virio Moloney murine leukemia virus genomic RNA dimerization domain.Journal of virology · 2010Article
- Influence of nucleotide identity on ribose 2'-hydroxyl reactivity in RNA.RNA (New York, N.Y.) · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Retroviruses selectively package two copies of their RNA genomes in the context of a large excess of nongenomic RNA. Specific packaging of genomic RNA is achieved, in part, by recognizing RNAs that form a poorly understood dimeric structure at their 5' ends. We identify, quantify the stability of, and use extensive experimental constraints to calculate a 3D model for a tertiary structure domain that mediates specific interactions between RNA genomes in a gamma retrovirus. In an initial interaction, two stem-loop structures from one RNA form highly stringent cross-strand loop-loop base pairs with the same structures on a second genomic RNA. Upon subsequent folding to the final dimer state, these intergenomic RNA interactions convert to a high affinity and compact tertiary structure, stabilized by interdigitated interactions between U-shaped RNA units. This retroviral conformational switch model illustrates how two-step formation of an RNA tertiary structure yields a stringent molecular recognition event at early assembly steps that can be converted to the stable RNA architecture likely packaged into nascent virions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.