Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2006
Gated myocardial perfusion single photon emission computed tomography in the clinical outcomes utilizing revascularization and aggressive drug evaluation (COURAGE) trial, Veterans Administration Cooperative study no. 424.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Impact of left ventricular function and the extent of ischemia and scar by stress myocardial perfusion imaging on prognosis and therapeutic risk reduction in diabetic patients with coronary artery disease: results from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Trial
- Myocardial perfusion imaging evidence of functionally complete revascularization by minimally invasive direct coronary artery bypass in 2-vessel coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyTrial
- Article
- Article
- Coronary Physiology Assessment for the Diagnosis and Treatment of Stable Ischemic Heart Disease.Current atherosclerosis reports · 2016Review
- Red Cell Distribution Width Can Predict the Significance of Angiographically Intermediate Coronary Lesions.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2016Article
- Clinical Relevance of Coronary Fractional Flow Reserve: Art-of-state.Chinese medical journal · 2015Review
- Safety and efficacy of a novel technique in the use of fractional flow reserve in complex coronary artery lesions.Chinese medical journal · 2015Article
- Lessons learned from MPI and physiologic testing in randomized trials of stable ischemic heart disease: COURAGE, BARI 2D, FAME, and ISCHEMIA.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Review
- Computed fractional flow reserve (FFTCT) derived from coronary CT angiography.Journal of cardiovascular translational research · 2013Review
- Importance of residual myocardial ischemia after intervention in the genesis of cardiovascular events among patients with chronic coronary artery disease.Current cardiology reports · 2011Review
- Strategies for defining an optimal risk-benefit ratio for stress myocardial perfusion SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Article
- The importance of the link between coronary artery calcification and myocardial ischemia: a developing argument.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStress gated myocardial perfusion single photon emission computed tomography (gSPECT) is increasingly used before and after intercurrent therapeutic intervention and is the basis for ongoing evaluation in the Department of Veterans Affairs clinical outcomes utilizing revascularization and aggressive drug evaluation (COURAGE) trial. METHODS AND
resultsThe COURAGE trial is a North American multicenter randomized clinical trial that enrolled 2287 patients to aggressive medical therapy vs percutaneous coronary intervention plus aggressive medical therapy. Three COURAGE nuclear substudies have been designed. The goals of substudy 0 are to examine the diagnostic accuracy of the extent and severity of inducible ischemia at baseline in COURAGE patients compared with patient symptoms and quantitative coronary angiography and to explore the relationship between inducible ischemia and the benefit from revascularization when added to medical therapy. Substudy 1 will correlate the extent and severity of provocative ischemia with the frequency, quality, and instability of recurrent symptoms in postcatheterization patients. Substudy 2 (n = 300) will examine the usefulness of sequential gSPECT monitoring 6 to 18 months after therapeutic intervention. Together, these nuclear substudies will evaluate the role of gSPECT to determine the effectiveness of aggressive risk-factor modifications, lifestyle interventions, and anti-ischemic medical therapies with or without revascularization in reducing patients' ischemic burdens.
conclusionsThe unfolding of evidence on the application of gSPECT in trials such as COURAGE defines a new era for nuclear cardiology. We hope the evidence that emerges from the COURAGE trial will further establish the role of nuclear imaging in the evidence-based management of patients with stable coronary disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.