ArticleDevelopmental biology2006
Mitochondrial distribution and microtubule organization in fertilized and cloned porcine embryos: implications for developmental potential.
Article in Developmental biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 72 citations in OpenAlex.
- Mitochondrial aggregation caused by cytochalasin B compromises the efficiency and safety of three-parent embryo.Molecular human reproduction · 2022Article
- Mitochondrial DNA Depletion in Granulosa Cell Derived Nuclear Transfer Tissues.Frontiers in cell and developmental biology · 2021Article
- Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells.Cell metabolism · 2020Article
- A single-cell analysis of the molecular lineage of chordate embryogenesis.Science advances · 2020Article
- A guiding torch at the poles: the multiple roles of spindle microtubule-organizing centers during cell division.Cell cycle (Georgetown, Tex.) · 2020Review
- Insights into the roles of sperm in animal cloning.Stem cell research & therapy · 2020Review
- Asymmetric inheritance of spindle microtubule-organizing centres preserves replicative lifespan.Nature cell biology · 2019Article
- Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria.Cellular and molecular life sciences : CMLS · 2019Review
- Assisted reproductive technologies to prevent human mitochondrial disease transmission.Nature biotechnology · 2017Article
- Mitochondria-targeted DsRed2 protein expression during the early stage of bovine somatic cell nuclear transfer embryo development.In vitro cellular & developmental biology. Animal · 2016Article
- Effect of acteoside on the re-localization and abnormal morphology of mitochondria in porcine oocytes during in vitro maturation.Journal of assisted reproduction and genetics · 2016Article
- The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility.Reproductive biology and endocrinology : RB&E · 2014Review
- Effect of mouse oocyte vitrification on mitochondrial membrane potential and distribution.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014Article
- Mouse Oocytes and Embryos Cryotop-vitrification Using Low Concentrated Solutions: Effects on Meiotic Spindle, Genetic Material Array and Developmental Ability.Iranian journal of basic medical sciences · 2013Article
- Mouse Oocytes and Embryos Cryotop-vitrification Using Low Concentrated Solutions: Effects on Meiotic Spindle, Genetic Material Array and Developmental Ability.Iranian journal of basic medical sciences · 2013Article
- RNA profiles of porcine embryos during genome activation reveal complex metabolic switch sensitive to in vitro conditions.PloS one · 2013Article
- Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription.Science signaling · 2012Article
- Cortical cytasters: a highly conserved developmental trait of Bilateria with similarities to Ctenophora.EvoDevo · 2011Article
- Doubly uniparental inheritance of mitochondria as a model system for studying germ line formation.PloS one · 2011Article
- Somatic cell nuclear transfer efficiency: how can it be improved through nuclear remodeling and reprogramming?Molecular reproduction and development · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Mitochondrial distribution and microtubule organization were examined in porcine oocytes after parthenogenesis, fertilization and somatic cell nuclear transfer (SCNT). Our results revealed that mitochondria are translocated from the oocyte's cortex to the perinuclear area by microtubules that either constitute the sperm aster in in vitro-fertilized (IVF) oocytes or originate from the donor cell centrosomes in SCNT oocytes. The ability to translocate mitochondria to the perinuclear area was lower in SCNT oocytes than in IVF oocytes. Sperm-induced activation rather than electrical activation of SCNT oocytes as well as the presence of the oocyte spindle enhanced perinuclear mitochondrial association with reconstructed nuclei, while removal of the oocyte spindle prior to sperm penetration decreased mitochondrial association with male pronuclei without having an apparent effect on microtubules. We conclude that factors derived from spermatozoa and oocyte spindles may affect the ability of zygotic microtubules to translocate mitochondria after IVF and SCNT in porcine oocytes. Mitochondrial association with pronuclei was positively related with embryo development after IVF. The reduced mitochondrial association with nuclei in SCNT oocytes may be one of the reasons for the low cloning efficiency which could be corrected by adding yet to be identified, sperm-derived factors that are normally present during physiological fertilization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.