ArticleBMC cardiovascular disorders2006
Heritability and major gene effects on left ventricular mass in the Chinese population: a family study.
Article in BMC cardiovascular disorders, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Pooled it
- Heart-Brain Axis: A Narrative Review of the Interaction between Depression and Arrhythmia.Biomedicines · 2024Review
- Multi-organ imaging-derived polygenic indexes for brain and body health.medRxiv : the preprint server for health sciences · 2024Article
- Family History of Hypertension and Echocardiographic Left Ventricular Hypertrophy in Hypertensive Nigerians.Global health, epidemiology and genomics · 2024Article
- Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images.Science (New York, N.Y.) · 2023Article
- Article
- Targeted next-generation sequencing for genetic variants of left ventricular mass status among community-based adults in Taiwan.Frontiers in genetics · 2022Article
- Association between insulin resistance and left ventricular hypertrophy in asymptomatic, Black, sub-Saharan African, hypertensive patients: a case-control study.BMC cardiovascular disorders · 2021Article
- Genetic approaches toward understanding the individual variation in cardiac structure, function and responses to exercise training.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021Review
- Association BetweenFrontiers in cardiovascular medicine · 2021Article
- Genome-Wide Analysis of Left Ventricular Image-Derived Phenotypes Identifies Fourteen Loci Associated With Cardiac Morphogenesis and Heart Failure Development.Circulation · 2019Article
- Marked variation in heritability estimates of left ventricular mass depending on modality of measurement.Scientific reports · 2019Article
- Genetically determined pattern of left ventricular function in normal and hypertensive hearts.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Left Ventricular Hypertrophy in Pediatric Hypertension: A Mini Review.Frontiers in pediatrics · 2017Review
- Rare Copy Number Variants Identified Suggest the Regulating Pathways in Hypertension-Related Left Ventricular Hypertrophy.PloS one · 2016Article
- Validation study of candidate single nucleotide polymorphisms associated with left ventricular hypertrophy in the Korean population.BMC medical genetics · 2015Article
- Left ventricular mechanical function: clinical correlates, heritability, and association with parental heart failure.European journal of heart failure · 2015Article
- Genetic epidemiology of left ventricular hypertrophy.American journal of cardiovascular disease · 2012Article
- Heritability of left ventricular structure and function in Caucasian families.European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology · 2011Article
- Electrocardiographic indices of left ventricular hypertrophy and repolarization phase share the same genetic influences: a twin study.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic components controlling for echocardiographically determined left ventricular (LV) mass are still unclear in the Chinese population.
methodsWe conducted a family study from the Chin-San community, Taiwan, and a total of 368 families, 1145 subjects, were recruited to undergo echocardiography to measure LV mass. Commingling analysis, familial correlation, and complex segregation analysis were applied to detect component distributions and the mode of inheritance.
resultsThe two-component distribution model was the best-fitting model to describe the distribution of LV mass. The highest familial correlation coefficients were mother-son (0.379, P < .0001) and father-son (0.356, P < .0001). Genetic heritability (h2) of LV mass was estimated as 0.268 +/- 0.061 (P < .0001); it decreased to 0.153 +/- 0.052 (P = .0009) after systolic blood pressure adjustment. Major gene effects with polygenic components were the best-fitting model to explain the inheritance mode of LV mass. The estimated allele frequency of the gene was 0.089.
conclusionThere were significant familial correlations, heritability and a major gene effect on LV mass in the population-based families.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.