ArticleAnalytical chemistry2006
Enhanced fluorescence of Cy5-labeled DNA tethered to silver island films: fluorescence images and time-resolved studies using single-molecule spectroscopy.
Article in Analytical chemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- A Modular Approach for the Synthesis of Diverse Heterobifunctional Cyanine Dyes.The Journal of organic chemistry · 2024Article
- Complementary Oligonucleotide Conjugated Multicolor Carbon Dots for Intracellular Recognition of Biological Events.ACS applied materials & interfaces · 2020Article
- Study on AgInZnS-Graphene Oxide Non-toxic Quantum Dots for Biomedical Sensing.Frontiers in chemistry · 2020Article
- Metal-Enhanced Fluorescence Study in Aqueous Medium by Coupling Gold Nanoparticles and Fluorophores Using a Bilayer Vesicle Platform.ACS omega · 2019Article
- Co-enhancement of fluorescence and singlet oxygen generation by silica-coated gold nanorods core-shell nanoparticle.Nanoscale research letters · 2014Article
- Photophysical behaviors of single fluorophores localized on zinc oxide nanostructures.International journal of molecular sciences · 2012Article
- Spatially selective photonic crystal enhanced fluorescence and application to background reduction for biomolecule detection assays.Optics express · 2011Article
- Prism-based spectral imaging of single-molecule fluorescence from gold-nanoparticle/fluorophore complex.Journal of fluorescence · 2011Article
- Photobleaching on photonic crystal enhanced fluorescence surfaces.Journal of fluorescence · 2011Article
- Enhanced Single-Molecule Detection using Porous Silver Membrane.The journal of physical chemistry. C, Nanomaterials and interfaces · 2010Article
- Fluorescent avidin-bound silver particle: a strategy for single target molecule detection on a cell membrane.Analytical chemistry · 2009Article
- Modification of single molecule fluorescence near metallic nanostructures.Laser & photonics reviews · 2009Article
- Plasmon-controlled fluorescence towards high-sensitivity optical sensing.Advances in biochemical engineering/biotechnology · 2009Review
- Metal-enhanced fluorescence of single green fluorescent protein (GFP).Biochemical and biophysical research communications · 2008Article
- Observation of Surface Plasmon Coupled Emission using Thin Platinum Films.Chemical physics letters · 2008Article
- Review
- Single-cell fluorescence imaging using metal plasmon-coupled probe 2: single-molecule counting on lifetime image.Nano letters · 2008Article
- Reduced blinking and long-lasting fluorescence of single fluorophores coupling to silver nanoparticles.Langmuir : the ACS journal of surfaces and colloids · 2008Article
- Single molecule photophysics near metallic nanostructures.Proceedings of SPIE--the International Society for Optical Engineering · 2008Article
- Single-Molecule Studies on Fluorescently Labeled Silver Particles: Effects of Particle Size.The journal of physical chemistry. C, Nanomaterials and interfaces · 2007Article
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Authors and funding
2 authors.
Funding
Abstract
Methods that increase the total emission per fluorophore would provide increased sensitivity and a wider dynamic range for chemical analysis, medical diagnostics, and in vivo molecular imaging. The use of fluorophore-metal interactions has the potential to dramatically increase the detectability of single fluorophores for bioanalytical monitoring. The fabrication and single-molecule analysis of fluorophore-labeled DNA molecules tethered to silver island films are described in this article. The single-molecule spectroscopic method reveals some insightful information on the behaviors of single molecules, rather than an ensemble of molecules. Analysis of fluorescence images, intensity profiles, total emitted photons, and lifetime distributions reveals some of sample heterogeneities. Investigations of time-dependent emission characteristics of single molecules indicate that the total number of emitted photons on the silvered surface is more than 10 times greater than on free labeled DNA molecules on a glass substrate. In addition, time-correlated single-photon counting results reveal the reduced lifetimes of single molecules tethered to silver island films.
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