ReviewWiener medizinische Wochenschrift (1946)2006
Malignant glioma: neuropathology and neurobiology.
Review in Wiener medizinische Wochenschrift (1946), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- Noninvasive assessment of glymphatic dysfunction and IDH mutation in glioma with DTI-ALPS and DTI metrics.Quantitative imaging in medicine and surgery · 2025Article
- Analysis of the glymphatic system function in high-grade glioma patients using diffusion tensor imaging along perivascular spaces.BMC neurology · 2025Article
- A Histopathologic Correlation Study Evaluating Glymphatic Function in Brain Tumors by Multiparametric MRI.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Peritumoral Brain Zone in Astrocytoma: Morphology, Molecular Aspects, and Clinical Manifestations (Review).Sovremennye tekhnologii v meditsine · 2024Review
- Identification and validation of a novel Parkinson-Glioma feature gene signature in glioma and Parkinson's disease.Frontiers in aging neuroscience · 2024Article
- Article
- Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop.Nature neuroscience · 2019Article
- Overexpression of the Kininogen-1 inhibits proliferation and induces apoptosis of glioma cells.Journal of experimental & clinical cancer research : CR · 2018Article
- Associations between EGFR gene polymorphisms and susceptibility to glioma: a systematic review and meta-analysis from GWAS and case-control studies.Oncotarget · 2017Article
- Novel drugs in pediatric gliomas.Oncology letters · 2017Article
- Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma.Oncology letters · 2017Article
- Article
- The ubiquitin-proteasome system in glioma cell cycle control.Cell division · 2012Article
- Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging.Neuro-oncology · 2012Article
- Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models.PloS one · 2011Article
- Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas.International journal of radiation oncology, biology, physics · 2010Article
- ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas.Clinical and experimental medicine · 2009Article
- Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors.The Journal of biological chemistry · 2009Article
- Assessment of a balloon-tipped catheter modified for intracerebral convection-enhanced delivery.Journal of neuro-oncology · 2008Article
- Correlation analysis between the expression of P21WAF1/CIP1, P16 proteins and human glioma.Clinical and experimental medicine · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malignant gliomas may manifest at any age including congenital and childhood cases. Peak incidence is, however, in adults older than 40 years. Males are more frequently affected than females. The sole unequivocal risk factor is therapeutic ionizing irradiation. Malignant gliomas comprise a spectrum of different tumor subtypes. Within this spectrum, glioblastoma, anaplastic astrocytoma and anaplastic oligodendroglioma share as basic features preferential location in cerebral hemispheres, diffuse infiltration of brain tissue, fast tumor growth with fatal outcome within months or years. Invasion is regarded as one of the main reasons for poor therapeutic success, because it makes complete surgical removal of gliomas impossible. Invasion of glioma cells requires interaction with the extracellular matrix and with surrounding cells of the healthy brain tissue. Vascular proliferates and tissue necrosis are characteristic features of malignant gliomas, in particular glioblastoma. These features are most likely the consequence of rapidly increasing tumor mass that is inadequately oxygenized by the preexisting vasculature. In malignant glioma, distinct molecular pathways including the p53 pathway, the RB pathway and the EGFR pathway show frequent alterations that seem to be pathogenetically relevant. Methylguanine-methyltransferase (MGMT) promoter methylation status in glioblastoma and 1p19q deletion status in anaplastic oligodendroglioma are associated with response to chemotherapy. The role of neuropathology and neurobiology in neurooncology is 1. to provide a clinically meaningful classification of brain tumors on basis of pathobiological factors, 2. to clarify etiology and pathogenesis of brain tumors as rational basis for development of new diagnostic tests and therapies, and 3. to translate testing for new clinically relevant molecular parameters into clinical application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.